Vincent Wiebach

TL;DR: The antibacterial microvionin contains two new lanthipeptide modifications, a triamino-dicarboxylic acid (avionin) and an N-terminal guanidino fatty acid, that lead to the establishment of the lipolanthine natural product class.

TL;DR: This analysis shed light on the evolution of microviridin biosynthesis and enabled prioritization of their chemo-enzymatic production, and advances the genome mining techniques available for natural product discovery and obviates the need to culture bacteria.

TL;DR: Three new sesquiterpenoids featured a 14-noreudesmane-type skeleton and were named hypoxylan A-C (7-9); the diterpenoid rickitin A (10) contains an abietane-type backbone.

TL;DR: The results provide general rules of substrate recruitment and enzymatic regulation during lipolanthine maturation, which will facilitate future efforts to rationally design new lanthipeptide scaffolds with antibacterial potency.

TL;DR: A systems analysis of secondary metabolite gene expression in the model strain Nostoc punctiforme PCC73102 using RNA-seq and fluorescence reporter analysis suggests that a combination of autocrine factors, a high CO2 level, and high light account for the upregulation of individual pathways.