V
Vineetha M. Zacharia
Researcher at University of California, Berkeley
Publications - 13
Citations - 873
Vineetha M. Zacharia is an academic researcher from University of California, Berkeley. The author has contributed to research in topics: Gene & Mutant. The author has an hindex of 7, co-authored 13 publications receiving 740 citations. Previous affiliations of Vineetha M. Zacharia include University of California & University of Texas Southwestern Medical Center.
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Journal ArticleDOI
The global, ppGpp‐mediated stringent response to amino acid starvation in Escherichia coli
Matthew F. Traxler,Sean M. Summers,Huyen-Tran Nguyen,Vineetha M. Zacharia,G. Aaron Hightower,Joel T. Smith,Tyrrell Conway +6 more
TL;DR: An experimental system based on starvation for isoleucine, which could be applied to both wild‐type Escherichia coli and the multiauxotrophic relA spoT mutant, presents a model that expands and functionally integrates the ppGpp‐mediated stringent response to include control of virtually all macromolecular synthesis and intermediary metabolism.
Journal ArticleDOI
Discretely calibrated regulatory loops controlled by ppGpp partition gene induction across the 'feast to famine' gradient in Escherichia coli.
Matthew F. Traxler,Vineetha M. Zacharia,Stafford Marquardt,Sean M. Summers,Huyen-Tran Nguyen,S. Elizabeth Stark,Tyrrell Conway +6 more
TL;DR: The data suggest that metabolic genes, i.e. those of the Lrp regulon, require only a low level of ppGpp for their induction, and that the RpoS regulon was induced only when high levels ofppGpp accumulated.
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Molecules to Ecosystems: Actinomycete Natural Products In situ.
TL;DR: It is suggested that investigating the ecology of actinomycetes interactions warrants particular attention with respect to metabolite discovery, and the implications for NP biosynthesis at ecosystem scales are considered.
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Microfold Cells Actively Translocate Mycobacterium tuberculosis to Initiate Infection.
Vidhya Nair,Luis H. Franco,Vineetha M. Zacharia,Haaris S. Khan,Chelsea E. Stamm,Wu You,Denise K. Marciano,Hideo Yagita,Beth Levine,Michael U. Shiloh +9 more
TL;DR: Using multiple mouse models, it is shown that Mtb invades via M cells to initiate infection and M cell translocation is a vital entry mechanism that contributes to the pathogenesis of Mtb.
Journal ArticleDOI
Assessment of the requirements for magnesium transporters in Bacillus subtilis.
TL;DR: It is speculated that the mgtE protein provides the primary route of magnesium import in B. subtilis and that the other putative transport proteins are likely to be utilized for more-specialized growth conditions.