[신간의 별자리x] 우리/미술, 그리고 ‘슬픔의 박물관’

Atom transfer radical polymerization.

New polymer synthesis by nitroxide mediated living radical polymerizations.

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Aryl-aryl bond formation one century after the discovery of the Ullmann reaction.

Metal-catalyzed living radical polymerization.

Viral and synthetic vectors for the delivery of nucleic acids were key to the rapid development of the extraordinarily efficient Covid-19 vaccines and of genetic nanomedicine. The four-component lipid nanoparticles, statistically distributed in nanoparticles, are the leading delivery non-viral vector used by BioNTech/Pfizer and Moderna to access their Covid-19 mRNA vaccines. Here we report the molecular design principles to target mRNA delivery and activity with a one-component ionizable multifunctional amphiphilic Janus dendrimer system derived from plant phenolic acids. The precise location of the functional groups in the one-component system demonstrates target being induced by the hydrophilic region and activity by the hydrophobic domain of the Janus. These principles, and a hypothetic mechanism explaining them, simplify preparation, handling and storage of vaccines, reduce price, while employing renewable starting materials. Therefore, an increased accessibility to a large diversity of mRNA-based vaccines and nanotherapeutics may become available by simple molecular design principles.

Virgil Percec

Papers

Molecular Design Principles to Target mRNA Delivery With One-Component Ionizable Amphiphilic Janus Dendrimers Derived From Plant Phenolic Acids