V
Virginia L. Gillespie
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 16
Citations - 439
Virginia L. Gillespie is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Virus & Viral replication. The author has an hindex of 8, co-authored 13 publications receiving 272 citations.
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Journal ArticleDOI
Comparison of Transgenic and Adenovirus hACE2 Mouse Models for SARS-CoV-2 Infection
Raveen Rathnasinghe,Shirin Strohmeier,Fatima Amanat,Virginia L. Gillespie,Florian Krammer,Adolfo García-Sastre,Lynda Coughlan,Lynda Coughlan,Michael Schotsaert,Melissa B. Uccellini +9 more
TL;DR: The K18-hACE2 model provides a stringent model for testing vaccines and antivirals, whereas the adenovirus delivery system has the flexibility to be used across multiple genetic backgrounds and modified mouse strains.
Journal ArticleDOI
The C terminus of p53 regulates gene expression by multiple mechanisms in a target- and tissue-specific manner in vivo
Pierre-Jacques Hamard,Nicolas J. Barthelery,Brandon Hogstad,Sathish Kumar Mungamuri,Crystal A. Tonnessen,Luis A. Carvajal,Emir Senturk,Virginia L. Gillespie,Stuart A. Aaronson,Miriam Merad,James J. Manfredi +10 more
TL;DR: The p53 tumor suppressor is a transcription factor that mediates varied cellular responses and regulates gene expression via multiple mechanisms depending on the tissue and target, and this leads to specific phenotypic effects in vivo.
Journal ArticleDOI
Morbid obesity resulting from inactivation of the ciliary protein CEP19 in humans and mice.
Adel Shalata,Adel Shalata,Maria Celeste M. Ramirez,Robert J. Desnick,Nolan Priedigkeit,Christoph Buettner,Claudia Lindtner,Mohammed Mahroum,Muhammad A. Abdul-Ghani,Feng Dong,Nazik Arar,Olga Camacho-Vanegas,Rui Zhang,Sandra Catalina Camacho,Ying Chen,Mwafaq Ibdah,Ralph A. DeFronzo,Virginia L. Gillespie,Kevin Kelley,Brian David Dynlacht,Sehyun Kim,Marc J. Glucksman,Zvi Borochowitz,John A. Martignetti +23 more
TL;DR: Loss of the ciliary protein CEP19 in humans and mice causes morbid obesity and defines a target for investigating the molecular pathogenesis of this disease and potential treatments for obesity and malnutrition.
Posted ContentDOI
Comparison of Transgenic and Adenovirus hACE2 Mouse Models for SARS-CoV-2 Infection.
Raveen Rathnasinghe,Shirin Strohmeier,Fatima Amanat,Virginia L. Gillespie,Florian Krammer,Adolfo García-Sastre,Lynda Coughlan,Michael Schotsaert,Melissa B. Uccellini +8 more
TL;DR: The K18-hACE2 transgenic model provides a stringent model for testing the ability of vaccines and antivirals to protect against disease, whereas the adenovirus delivery system has the flexibility to be used across multiple genetic backgrounds and modified mouse strains.
Journal ArticleDOI
Contribution of the Purinergic Receptor P2X7 to Development of Lung Immunopathology during Influenza Virus Infection
Victor H. Leyva-Grado,Megan E. Ermler,Michael Schotsaert,Ma G. Gonzalez,Virginia L. Gillespie,Jean K. Lim,Adolfo García-Sastre +6 more
TL;DR: The results demonstrate that activation of the P2X7 receptor is involved in the exacerbated immune response observed during influenza virus infection and helps to better understand the mechanisms leading to the lung immunopathology observed during severe viral infections.