Vit Janota

TL;DR: The heterogeneity of protein structure is a fundamental limitation to the use of such spectral analysis methods, and the underutilization of these data for prediction of secondary structure suggests spectral data could predict a more detailed descriptor.

TL;DR: A family of minimally cross-hybridizing nucleotide sequences, methods of use, and a specific family of 210 24mers is described in this paper, which is based on the same approach as the one described in this paper.

TL;DR: This study is based primarily on the optimization of the calculation to predict FC values for proteins not included in the reference data set used for regression, and the best prediction is obtained with the function using only part of the observable independent VCD spectral components.

TL;DR: An extension to standard protein secondary structure predictions using optical spectra that encompasses the number and average lengths of segments of uniform secondary structure in the sequence is demonstrated and shows that the matrix descriptor can be predicted to an accuracy comparable to that of conventionally predicted average fractional secondary structures.

TL;DR: Results show that the effects of partial deuteration on the VCD spectra band shape are predictable from the H2O spectra, and Insight into the details of how the neural networks encode and process the spectroscopic information is derived from a spectral representation of these weight matrices.