V
Vlad Edward Gregor
Publications - 8
Citations - 921
Vlad Edward Gregor is an academic researcher. The author has contributed to research in topics: Tyrosine kinase & Prodrug. The author has an hindex of 5, co-authored 8 publications receiving 862 citations.
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Activating mutations in ALK provide a therapeutic target in neuroblastoma
Rani E. George,Takaomi Sanda,Megan Hanna,Stefan Fröhling,William Luther,Jianming Zhang,Yebin Ahn,Wenjun Zhou,Wendy B. London,Patrick McGrady,Liquan Xue,Sergey Zozulya,Vlad Edward Gregor,Thomas R. Webb,Nathanael S. Gray,D. Gary Gilliland,Lisa Diller,Heidi Greulich,Stephan W. Morris,Matthew Meyerson,A. Thomas Look +20 more
TL;DR: In this paper, the authors reported the detection of previously unknown mutations in the ALK gene, which encodes a receptor tyrosine kinase, in 8% of primary neuroblastomas.
Patent
Heterocyclic compounds as tyrosine kinase modulators
Alexey Vyacheslavovich Anikin,Vidyasagar Reddy Gantla,Vlad Edward Gregor,Luyong Jiang,Yahu A. Liu,Danny P. C. McGee,Charles Mikel,Jason C. Pickens,Thomas R. Webb,Yan Zheng,Tong Zhu,Aleksander Kadushkin,Sergey Zozulya,Alexander Chucholowski,Douglas Eric Mcgrath,Sergey Sviridov +15 more
TL;DR: In this paper, the present invention provides compounds (1 to 6) capable of modulating tyrosine kinases, compositions comprising the compounds and methods of their use (Formulaes I to VI).
Patent
Novel tyrosine kinase inhibitors
Vlad Edward Gregor,Yahu A. Liu,Alexey Vyacheslavovich Anikin,Charles Mikel,Douglas Eric Mcgrath,Goverdhan Reddy Vavilala,Jason C. Pickens,Aleksander Kadushkin,Luyong Jiang,Mohan Thiruvazhi,Sergey Zozulya,Rajendran Vairagoundar,Tong Zhu,Alexander Chucholowski,Zheng Yan,Alisher Khasanov +15 more
TL;DR: In this paper, compounds of the formula (I): or a stereoisomer, tautomer, salt, hydrate or prodrug thereof, compositions comprising the compounds and methods of their use.
Patent
Tricyclic compounds and its use as tyrosine kinase modulators
Vlad Edward Gregor,Yahu A. Liu,Alexey Vyacheslavovich Anikin,Danny P. C. McGee,Charles Mikel,Douglas Eric Mcgrath,Goverdhan Reddy Vavilala,Jason C. Pickens,Alexander Kadushkin,Mohan Thiruvazhi,Sergey Zozulya,Rajendran Vairagoundar,Tong Zhu,Alexander Chucholowski,Thomas R. Webb,Luyong Jiang,Vidyasagar Reddy Gantla,Zheng Yan +17 more
TL;DR: In this paper, the authors present a set of compounds of formula (I) or a stereoisomer, tautomer, salt, hydrate or prodrug capable of modulating tyrosine kinases, compositions comprising the compounds and methods of their use.
Patent
Tricyclic compound derivatives useful in the treatment of neoplastic diseases, inflammatory disorders and immunomodulatory disorders
Vlad Edward Gregor,Yahu A. Liu,Alexey Vyacheslavovich Anikin,Danny P. C. McGee,Charles Mikel,Douglas Eric Mcgrath,Goverdhan Reddy Vavilala,Jason C. Pickens,Alexander Kadushkin,Mohan Thiruvazhi,Sergey Zozulya,Rajendran Vairagoundar,Tong Zhu,Alexander Chucholowski,Thomas R. Webb,Luyong Jiang,Vidyasagar Reddy Gantla,Zheng Yan +17 more
TL;DR: In this article, the authors present a set of compounds of formula (I) or a stereoisomer, tautomer, salt, hydrate or prodrug capable of modulating tyrosine kinases, compositions comprising the compounds and methods of their use.