J
Jianming Zhang
Researcher at Harvard University
Publications - 72
Citations - 11520
Jianming Zhang is an academic researcher from Harvard University. The author has contributed to research in topics: Kinase & Gene. The author has an hindex of 39, co-authored 69 publications receiving 10411 citations. Previous affiliations of Jianming Zhang include University of Chicago & Shanghai Jiao Tong University.
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Journal ArticleDOI
Targeting cancer with small molecule kinase inhibitors
TL;DR: This Review provides a broad overview of some of the approaches currently used to discover and characterize new kinase inhibitors, and discusses the current challenges in the field.
Journal ArticleDOI
An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1.
Carson C. Thoreen,Seong A. Kang,Jae Won Chang,Qingsong Liu,Jianming Zhang,Yi Gao,Laurie J. Reichling,Taebo Sim,David M. Sabatini,Nathanael S. Gray +9 more
TL;DR: It is found that Torin1, a highly potent and selective ATP-competitive mTOR inhibitor that directly inhibits both complexes, impairs cell growth and proliferation to a far greater degree than rapamycin.
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Activating mutations in ALK provide a therapeutic target in neuroblastoma
Rani E. George,Takaomi Sanda,Megan Hanna,Stefan Fröhling,William Luther,Jianming Zhang,Yebin Ahn,Wenjun Zhou,Wendy B. London,Patrick McGrady,Liquan Xue,Sergey Zozulya,Vlad Edward Gregor,Thomas R. Webb,Nathanael S. Gray,D. Gary Gilliland,Lisa Diller,Heidi Greulich,Stephan W. Morris,Matthew Meyerson,A. Thomas Look +20 more
TL;DR: In this paper, the authors reported the detection of previously unknown mutations in the ALK gene, which encodes a receptor tyrosine kinase, in 8% of primary neuroblastomas.
Journal ArticleDOI
Systematic Identification of Culture Conditions for Induction and Maintenance of Naive Human Pluripotency
Thorold W. Theunissen,Benjamin E. Powell,Haoyi Wang,Maya Mitalipova,Dina A. Faddah,Jessica Reddy,Zi Peng Fan,Dorothea Maetzel,Kibibi Ganz,Linyu Shi,Tenzin Lungjangwa,Sumeth Imsoonthornruksa,Yonatan Stelzer,Sudharshan Rangarajan,Ana C. D’Alessio,Jianming Zhang,Qing Gao,Meelad M. Dawlaty,Richard A. Young,Nathanael S. Gray,Rudolf Jaenisch +20 more
TL;DR: In this paper, the authors identify small molecules that support self-renewal of naive human ESCs based on maintenance of endogenous OCT4 distal enhancer activity, a molecular signature of ground state pluripotency.
Journal ArticleDOI
MEK1 mutations confer resistance to MEK and B-RAF inhibition
Caroline Emery,Krishna G. Vijayendran,Marie C. Zipser,Allison M. Sawyer,Lili Niu,Jessica J. Kim,Charlie Hatton,Rajiv Chopra,Patrick A. Oberholzer,Patrick A. Oberholzer,Patrick A. Oberholzer,Maria B. Karpova,Laura E. MacConaill,Jianming Zhang,Nathanael S. Gray,William R. Sellers,Reinhard Dummer,Levi A. Garraway,Levi A. Garraway +18 more
TL;DR: The results affirm the importance of MEK dependency in BRAF-mutant melanoma and suggest novel mechanisms of resistance to MEK and B-RAF inhibitors that may have important clinical implications.