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Sergey Zozulya
Researcher at Enamine Ltd
Publications - 148
Citations - 4458
Sergey Zozulya is an academic researcher from Enamine Ltd. The author has contributed to research in topics: Taste receptor & Taste. The author has an hindex of 30, co-authored 145 publications receiving 4194 citations. Previous affiliations of Sergey Zozulya include Russian Academy of Sciences & University of Southern California.
Papers
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Journal ArticleDOI
Activating mutations in ALK provide a therapeutic target in neuroblastoma
Rani E. George,Takaomi Sanda,Megan Hanna,Stefan Fröhling,William Luther,Jianming Zhang,Yebin Ahn,Wenjun Zhou,Wendy B. London,Patrick McGrady,Liquan Xue,Sergey Zozulya,Vlad Edward Gregor,Thomas R. Webb,Nathanael S. Gray,D. Gary Gilliland,Lisa Diller,Heidi Greulich,Stephan W. Morris,Matthew Meyerson,A. Thomas Look +20 more
TL;DR: In this paper, the authors reported the detection of previously unknown mutations in the ALK gene, which encodes a receptor tyrosine kinase, in 8% of primary neuroblastomas.
Journal ArticleDOI
Calcium-myristoyl protein switch.
Sergey Zozulya,Lubert Stryer +1 more
TL;DR: The findings suggest that the binding of Ca2+ to recoverin has two effects: (i) hydrophobic surfaces are exposed, allowing the protein to interact with complementary nonpolar sites, such as the aromatic rings of phenyl-agarose; and (ii) the myristoyl group is extruded, enabling recoverin to insert into a lipid bilayer membrane.
Journal ArticleDOI
The human olfactory receptor repertoire
TL;DR: The identification and cloning of all functional human odorant receptor genes is an important initial step in understanding receptor-ligand specificity and combinatorial encoding of odorant stimuli in human olfaction.
Journal ArticleDOI
Three-dimensional structure of recoverin, a calcium sensor in vision
TL;DR: The crystal structure of recombinant unmyristoylated recoverin, a recently discovered member of the EF hand superfamily, serves as a calcium sensor in vision by arranging the four EF hands in a compact array that contrasts with the dumbbell shape of calmodulin and troponin C.
Patent
T1R taste receptors and genes encoding same
TL;DR: In this article, T2R taste G Protein-Coupled Receptors that are believed to be involved in bitter taste sensation, and the genes encoding the same, are described, along with methods for isolating such genes and for isolate and expressing such receptors.