Vladimir S. Mashanov

TL;DR: These recent studies on visceral regeneration in holothurians provide a unique view that complements regeneration studies in other animal phyla, which are mainly focused on whole-animal regeneration or appendage regeneration.

TL;DR: High-throughput sequencing is employed to analyze the transcriptome of the normal and regenerating radial nerve cord in the sea cucumber Holothuria glaberrima, corroborating existing data on cellular mechanisms implicated in regeneration in sea cucumbers and laying out a roadmap for future studies of regulatory mechanisms.

TL;DR: The data suggest that differentiated cells of echinoderms are capable of transdifferentiation into other cell types, and this study provides an example of an alternative mechanism of tissue repair in the holothurian Eupentacta fraudatrix.

TL;DR: Visceral regeneration in the sea cucumber H. glaberrima is accompanied by elevated levels of cell division and cell death, and, moreover, involves expression of pro-cancer genes, such as survivin and mortalin, which are known to support proliferation and inhibit apoptosis.

TL;DR: Non-radioactive in situ hybridization techniques are employed, which combine good tissue morphology preservation with high sensitivity of transcript detection, to map gene expression in the regenerating digestive tube of the sea cucumber Holothuriaglaberrima, to highlight the gut mesothelium as a highly dynamic tissue, whose cells undergo remarkable changes in their phenotype and geneexpression in response to injury.