V
Vladimir S. Prassolov
Researcher at Engelhardt Institute of Molecular Biology
Publications - 98
Citations - 1698
Vladimir S. Prassolov is an academic researcher from Engelhardt Institute of Molecular Biology. The author has contributed to research in topics: Gene & RNA interference. The author has an hindex of 21, co-authored 89 publications receiving 1428 citations. Previous affiliations of Vladimir S. Prassolov include National Cancer Research Institute & Russian Academy of Sciences.
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Coordinated interaction of multifunctional members of the p53 family determines many key processes in multicellular organisms
TL;DR: The p53 family is comprised of three genes—TP53, TP63, and TP73—each of which is expressed as a set of structurally and functionally different isoforms, forming a united functional network of proteins.
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A new bidirectional promoter from the human genome
A. S. Orekhova,P. S. Sverdlova,P. V. Spirin,Olga G. Leonova,Vladimir I. Popenko,Vladimir S. Prassolov,Petr M. Rubtsov +6 more
TL;DR: A novel bidirectional promoter was cloned from the human genome; it can be used for simultaneous constitutive expression of two different genes in human cells.
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Key role of the internal 5′-UTR segment in the transcription activity of the human L1 retrotransposon
Ivan Olovnikov,Z. V. Adyanova,Evgeniy R. Galimov,Dmitri E. Andreev,Ilya M. Terenin,Dmitry Ivanov,Vladimir S. Prassolov,Sergey E. Dmitriev +7 more
TL;DR: This study shows that 5′-UTR internal segment 390–662, containing numerous binding sites for various transcription factors, is indispensable for effective L1 transcription and can be considered as a transcriptional enhancer.
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[Ribonuclease binase induces death in T-cell acute lymphoblastic leukemia cells by apoptosis].
K. M. Burnysheva,I. Yu. Petrushanko,P. V. Spirin,Vladimir S. Prassolov,Alexander A. Makarov,Vladimir A. Mitkevich +5 more
TL;DR: It is found that the treatment of cancer cells with binase leads to a reduction in reactive oxygen species and transcription factor NFκB levels, and it is demonstrated that these effects are a common feature of the action of RNases on cancer cells.
Journal Article
Polymorphic changes of cell phenotype caused by elevated expression of an exogenous NEU proto-oncogene.
Alexander M. Tarakhovsky,Resnikov M,Tetiana Zaichuk,Tugusheva Mv,Butenko Za,Vladimir S. Prassolov +5 more
TL;DR: The results suggest the existence of unknown host-specific factor(s) determining the response of cells to NEU overexpression, and suggest the formation of new NEU proto-oncogene with extensive homology to epidermal growth factor receptor.