V
Vladimir S. Prassolov
Researcher at Engelhardt Institute of Molecular Biology
Publications - 98
Citations - 1698
Vladimir S. Prassolov is an academic researcher from Engelhardt Institute of Molecular Biology. The author has contributed to research in topics: Gene & RNA interference. The author has an hindex of 21, co-authored 89 publications receiving 1428 citations. Previous affiliations of Vladimir S. Prassolov include National Cancer Research Institute & Russian Academy of Sciences.
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Viral fibrotic scoring and drug screen based on MAPK activity uncovers EGFR as a key regulator of COVID-19 fibrosis.
TL;DR: In this article, a correlation matrix based on the transcriptomic data of patients with idiopathic pulmonary fibrosis was established and identified a cluster of genes responsible for SARS-CoV-2-fibrosis including ACE2 and epidermal growth factor EGF.
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Two Receptors, Two Isoforms, Two Cancers: Comprehensive Analysis of KIT and TrkA Expression in Neuroblastoma and Acute Myeloid Leukemia
T D Lebedev,Elmira Vagapova,Vladimir I. Popenko,O. G. Leonova,Pavel Spirin,Vladimir S. Prassolov +5 more
TL;DR: This work provided a comprehensive characterization of TrkA and KIT expression along with the oncogenic signatures of these genes across two pediatric tumors and identified several gene sets both unique and common for pediatric AML and NB.
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Phosphoramidate derivatives of acyclovir: synthesis and antiviral activity in HIV-1 and HSV-1 models in vitro.
N. F. Zakirova,Alexander V. Shipitsyn,Maxim V. Jasko,M M Prokofjeva,Valeria L. Andronova,Galegov Ga,Vladimir S. Prassolov,Sergey N. Kochetkov +7 more
TL;DR: The antiviral activity against HIV and HSV and the chemical stability of ACV phosphoramidate derivatives were studied and the best compound appeared to be 9-(2-hydroxymethyl)guanine phosphoromonomorpholidate (7), which inhibited virus replication in pseudo-HIV-1 particles by 50% at 50 μM.
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Therapy of HIV Infection: Current Approaches and Prospects
TL;DR: A traditional approach involving HIV-1 inhibitors as well as the prospects of other treatment options are described, including the use of neutralizing antibodies, genome editing, and blocking an integrated latent provirus.
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Activated leukemic oncogenes AML1-ETO and c-kit: role in development of acute myeloid leukemia and current approaches for their inhibition.
TL;DR: Inhibiting expression of activated leukemic oncogenes based on the principle of RNA interference seems to be a promising approach in this field of oncologic diseases.