W
W. C. Knowler
Researcher at National Institutes of Health
Publications - 108
Citations - 12520
W. C. Knowler is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Diabetes mellitus & Population. The author has an hindex of 53, co-authored 108 publications receiving 11981 citations. Previous affiliations of W. C. Knowler include University of Leeds & University College London.
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Journal ArticleDOI
Predisposition to hypertension and susceptibility to renal disease in insulin-dependent diabetes mellitus.
Andrzej S. Krolewski,Mitzy Canessa,James H. Warram,Lori M.B. Laffel,A R Christlieb,W. C. Knowler,Larry Rand +6 more
TL;DR: The risk of renal disease in patients with juvenile-onset insulin-dependent diabetes is associated with a genetic predisposition to hypertension, and this appears to increase susceptibility for renal disease principally in Patients with poor glycemic control.
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Predictors of Progression From Impaired Glucose Tolerance to NIDDM: An Analysis of Six Prospective Studies
Sharon L. Edelstein,W. C. Knowler,R P Bain,Reubin Andres,Elizabeth Barrett-Connor,G K Dowse,S. M. Haffner,David J. Pettitt,John D. Sorkin,Denis C. Muller,V R Collins,Richard F. Hamman +11 more
TL;DR: Analysis of data from six prospective studies indicates that persons with IGT are at high risk of NIDDM and that further refinement of risk can be made by other simple measurements, and the ability to identify persons at high Risk should facilitate clinical trials in diabetes prevention.
Journal ArticleDOI
Long-term Effects of Lifestyle Intervention or Metformin on Diabetes Development and Microvascular Complications: the DPP Outcomes Study
David M. Nathan,Elizabeth Barrett-Connor,Jill P. Crandall,S. L. Edelstein,Ronald B. Goldberg,Edward S. Horton,W. C. Knowler,Kieren J. Mather,Trevor J. Orchard,Xavier Pi-Sunyer,David Schade,M. Temprosa +11 more
TL;DR: Lifestyle intervention or metformin significantly reduce diabetes development over 15 years, and those who did not progress to diabetes had a lower prevalence of microvascular complications than those who progressed.
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The 1997 American Diabetes Association and 1999 World Health Organization criteria for hyperglycemia in the diagnosis and prediction of diabetes.
Momin M. Gabir,Robert L. Hanson,Dana Dabelea,G Imperatore,Janine Roumain,Peter H. Bennett,W. C. Knowler +6 more
TL;DR: The prevalence and incidence of diabetes are somewhat lower with the ADA criteria than with the 1985 or 1999 WHO criteria, and the intermediate categories of glycemia differ substantially, although a smaller number of people who are at higher risk of developing diabetes than those with IGT.
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Comparison of tests for glycated haemoglobin and fasting and two hour plasma glucose concentrations as diagnostic methods for diabetes
D. R. McCance,Robert L. Hanson,Marie-Aline Charles,Lennart T. H. Jacobsson,David J. Pettitt,Peter H. Bennett,W. C. Knowler +6 more
TL;DR: It is suggested that determination of glycated haemoglobin or fasting plasma glucose concentrations alone may be acceptable alternatives to measuring glucose concentration two hours after challenge with 75 g glucose for the diagnosis of diabetes.