https://zhiyuan.sjtu.edu.cn/file/course/20151117094407_The%20c-fms%20Proto-oncogene%20Product%20Is%20Related%20to%20the%20Receptor%20for%20the%20Mononuclear%20Phagocyte%20Growth%20Factor.pdf

The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF 1

From the combination of knowledge and actions, someone can improve their skill and ability. It will lead them to live and work much better. This is why, the students, workers, or even employers should have reading habit for books. Any book will give certain knowledge to take all benefits. This is what this the interferon system tells you. It will add more knowledge of you to life and work better. Try it and prove it.

The Interferon System

A tumor cell line was derived from the fibrosarcoma of a 35-year-old Caucasian man who died without having received chemotherapy or radiotherapy. The in vitro growth properties and transplantability into antithymocytic sera treated mice were characteristic of these malignant cells. An aberrant karyology with marker chromosomes was present. No virus particles were detected. Cancer 33:1027-1033, 1974. ERMANENT CELL LINES FROM ANIMAL TISSUES P were established as early as 1948.23 Most of these were originated from malignant tissues. Although a number of human cell lines have been established in vitro, very few fibrosarcoma cell lines have been described. As far as we are aware, there are reports of approximately eight cell lines derived from osteogenic sarcomas,1,4,Q,10,13,~1 two on rhabdomyosarcoma,12)26 three on liposarcoma,1.9.10 and one each on giant cell sarcomas,l Kaposi's sarcoma,* neurogenic sarcoma,26 synovioma,lO and fibrosarcoma.l The rest of the reported cell lines are all carcinomas. Only a few of these sarcoma cell lines have been fully studied and characterized. In this paper we describe the properties of a tumor cell line (HT1080) derived from a fibrosarcoma of a human male.

Characterization of a newly derived human sarcoma cell line (ht-1080)

A new acute transforming feline retrovirus, the Hardy-Zuckerman 4 feline sarcoma virus (HZ4-FeSV), has been isolated from a feline fibrosarcoma The viral genome of HZ4-FeSV contains a new oncogene designated v-kit, has the structure 5' delta gag-kit-delta pol-delta env 3' and specifies a gag-kit polyprotein of relative molecular mass 80,000 The predicted kit amino-acid sequence displays partial homology with tyrosine-specific protein kinase oncogenes HZ4-FeSV appears to have been generated by transduction of feline c-kit sequences with feline leukaemia virus

A new acute transforming feline retrovirus and relationship of its oncogene v-kit with the protein kinase gene family

Molecular cloning of the genes for several members of a family of gly­ coproteins, the hematopoietic growth factors (HGFs), has transformed experimental hematology. Molecular probes have been used to investigate the cellular source of the HGFs and the mechanism by which their genes are regulated. Recombinant purified HGFs have been used to investigate their functions in vitro, the binding characteristics of their receptors, and the isolation of certain receptor cDNAs. This increase in knowledge of the cellular biology

/pdf/hematopoietic-growth-factors-4pm3kuwi85.pdf

Hematopoietic growth factors.

Summary Histological examination of an invasive neoplasm from an 18-month-old female domestic shorthair cat revealed it to be a pleomorphic fibrosarcoma that ranged in microscopic appearance from well-differentiated collagenous connective tissue to anaplastic sarcomatous tissue that infiltrated surrounding musculature and skin. The fibrosarcoma was transmitted by whole cells or cell-free preparations to 8 to 10 neonatal kittens. The original neoplasm and the induced fibrosarcomas that were examined electron microscopically contained mature and budding C-type particles. Immunodiffusion studies with serum prepared in rabbits against purified ether-disrupted feline leukemia virus revealed identity between the feline leukemia virus group-specific antigen and extracts of the original fibrosarcoma.

https://cancerres.aacrjournals.org/content/canres/31/7/953.full.pdf

A transmissible feline fibrosarcoma of viral origin.

Felinie leutkemia viruts antigen is demonstrable by immunodiffusion with rabbit precipitating antiserum to purified felinie leukemia virus. The felinie leukemia virus antigen was found in the tissues of 25 of 33 cats with lymphosarcoma and of 5 of 13 cats with infectious peritonitis. Its presence was correlated with the occurrence of felinie leukemia virus demonstrable by electron microscopy. The one clinically normal cat giving a positive test for feline leukemia virus antigen belonged to a household in which two cats had developed lymphosarcoma. With the exception of a dog with lymphosarcoma induced by feline leukemia virus, the antigent was absent from lymphosarcoma and nonlymphomatous tumors of other species (man, dog, cow, goat, or pig).

Feline leukemia virus: occurrence of viral antigen in the tissues of cats with lymphosarcoma and other diseases.

Shared group-specific antigen of murine and feline leukemia viruses

Forty-two kittens and 28 adult cats were placed as tracers in leukemia cluster environments in contact with resident cats, 30% of which were persistently infected with feline leukemia virus (FeLV). After 7 months exposure, FeLV viremia had been detected in 71% of the tracer kittens, although only 55% of these remained persistently infected; in the same period, 11% of tracer adults became infected, but by 2 years the figure reached 43%. Mean latent periods before detection of viremia were 3.4 +/- 1.8 (S.D.) and 13.0 +/- 5.9 months for kittens and adults, respectively. First detection of FeLV infection was accompanied by a sharp although transient drop in peripheral white blood cell numbers, and infection onset triggered the humoral immune response which was comprised of separate antibodies with virus-neutralizing and tumor lysis activities. High titers of virus-neutralizing antibody appeared in transiently viremic cats immediately following elimination of viremia; this antibody was rarely detected in cats that remained persistently viremic. Lytic complement-dependent antibody to feline oncornavirus-associated cell membrane antigen appeared in most cats 1 to 2 weeks after FeLV infection was first detected, and subsequently high titers of this antibody remained in both transiently and persistently infected cats. If the rate of FeLV infection was summarized by using viremia and/or antibody appearance, then 95% of the kittens became infected within 1 year and 61% of the adults within 2 years. Adult cats are, therefore, susceptible to FeLV infection following long-term natural exposure, and their apparent resistance cannot be attributed to a protective humoral immune response that developed immediately after exposure commenced.

https://cancerres.aacrjournals.org/content/canres/40/3/823.full.pdf

Natural Feline Leukemia Virus Infection and the Immune Response of Cats of Different Ages

IN an effort to rescue components of a hypothetical human sarcoma virus genome1,2, a human rhabdomyosarcoma (RD) cell line3 was infected with the GA strain of FeLV4 or the rat-tropic Kirsten strain of murine sarcoma virus5 and virus productive cell lines were established. During these studies the RD-114 virus was accidentally discovered6,7 and it became of interest to compare the properties of the four cell lines (parent RD cells, RD-114 cells, RD-FeLV cells and RD-KiMSV cells) and the viruses released from three of the lines (RD-114 virus, RD-FeLV virus, RD-KiMSV virus).

W. D. Hardy

Papers

A transmissible feline fibrosarcoma of viral origin.

Feline leukemia virus: occurrence of viral antigen in the tissues of cats with lymphosarcoma and other diseases.

Shared group-specific antigen of murine and feline leukemia viruses

Natural Feline Leukemia Virus Infection and the Immune Response of Cats of Different Ages

RD-114 virus compared with feline and murine type-C viruses released from RD cells.