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W. S. Bloom
Researcher at University of Geneva
Publications - 5
Citations - 693
W. S. Bloom is an academic researcher from University of Geneva. The author has contributed to research in topics: Cytoskeleton & Actin. The author has an hindex of 4, co-authored 5 publications receiving 691 citations.
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Actin expression in smooth muscle cells of rat aortic intimal thickening, human atheromatous plaque, and cultured rat aortic media.
TL;DR: This pattern of actin expression represents a new reliable protein-chemical marker of experimental and human atheromatous smooth muscle cells and is presented as a novel marker of rat and human aortic intimal thickening.
Journal Article
Cytoskeleton of rat aortic smooth muscle cells. Normal conditions and experimental intimal thickening.
TL;DR: The organization of actin, vimentin, and desmin in smooth muscle cells of rat aortic media and intima under normal conditions and 15 or 75 days after endothelial injury has been studied by means of electron microscopy, indirect immunofluorescence, densitometric analysis of sodium dodecyl sulfate-polyacrylamide gels, isoelectric focusing, and bidimensional gels.
Journal Article
Cytoskeletal remodeling of rat aortic smooth muscle cells in vitro: relationships to culture conditions and analogies to in vivo situations.
TL;DR: During culture SMC develop features similar to those observed in normal foetal SMC or in SMC present in atheromatous plaques; this model may be useful for the understanding of mechanisms leading to SMC differentiation and to atheroma formation.
Journal Article
The cytoskeleton of rat aortic smooth muscle cells: normal conditions and experimental intimal thickening
TL;DR: Intimal smooth muscle cells are less numerous than 15 days after injury, and the organization of their cytoskeletal elements has reverted almost to normal conditions, while at both 15 and 75 days after endothelial injury, no significant changes of cytoskeleton elements are seen in the aortic media underlying intimal thickenings.
The cytoskeleton of rat aortic smooth muscle cells (SMC) in vitro: Relationships to culture conditions and replicative activity
TL;DR: The results show that the modifications of cytoskeletal elements during intimal thickening or tissue culture furnish new useful information on S M C reaction to stimuli inducing their replication and movement.