1,2-Amino Alcohols and Their Heterocyclic Derivatives as Chiral Auxiliaries in Asymmetric Synthesis

Oxidation reactions are of fundamental importance in nature, and are key transformations in organic synthesis. The development of new processes that employ transition metals as substrate-selective catalysts and stoichiometric environmentally friendly oxidants, such as molecular oxygen or hydrogen peroxide, is one of the most important goals in oxidation chemistry. Direct oxidation of the catalyst by molecular oxygen or hydrogen peroxide is often kinetically unfavored. The use of coupled catalytic systems with electron-transfer mediators (ETMs) usually facilitates the procedures by transporting the electrons from the catalyst to the oxidant along a low-energy pathway, thereby increasing the efficiency of the oxidation and thus complementing the direct oxidation reactions. As a result of the similarities with biological systems, this can be dubbed a biomimetic approach.

Catalytic Oxidation of Organic Substrates by Molecular Oxygen and Hydrogen Peroxide by Multistep Electron Transfer : A Biomimetic Approach

Recoverable Catalysts for Asymmetric Organic Synthesis

The formation of oxygen–carbon bonds is one of the fundamental transformations in organic synthesis. In this regard the application of palladium-based catalysts has been extensively studied during recent years. Nowadays it is an established methodology and the success has been proven in manifold synthetic procedures. This tutorial review summarizes the advances on palladium-catalysed C–O bond formation, means hydroxylation and alkoxylation reactions.

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Palladium-catalysed hydroxylation and alkoxylation

Ion exchange resins: catalyst recovery and recycle.

A mechanistic insight leads to a greatly improved osmium-catalyzed asymmetric dihydroxylation process

Documenting the scope of the catalytic asymmetric dihydroxylation

Compounds of Formula I are inhibitors of HIV integrase and inhibitors of HIV replication: the asterisk * in Q denotes the point of attachment to the rest of the compound; and n, L1, L2, X1, X2, X3, Y, Z, R1, R2 and R3 are defined herein. The compounds are useful for the prophylaxis or treatment of infection by HIV and the prophylaxis, treatment, or delay in the onset or progression of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se (or as hydrates or solvates thereof) or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.

Bridged compounds as hiv integrase inhibitors

The present invention relates to Spirocyclic Heterocycle Compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, B, X, R 1 , R 2 , R 3 and R 4 are as defined herein. The present invention also relates to compositions comprising at least one Spirocyclic Heterocycle Compound, and methods of using the Spirocyclic Heterocycle Compounds for treating or preventing HIV infection in a subject.

Wai John S

Papers

A mechanistic insight leads to a greatly improved osmium-catalyzed asymmetric dihydroxylation process

Documenting the scope of the catalytic asymmetric dihydroxylation

Bridged compounds as hiv integrase inhibitors

Spirocyclic heterocycle compounds useful as hiv integrate inhibitors

Documenting the Scope of the Catalytic Asymmetric Dihydroxylation.