W
Wai Lee T. Wong
Researcher at Genentech
Publications - 9
Citations - 1688
Wai Lee T. Wong is an academic researcher from Genentech. The author has contributed to research in topics: Receptor & Receptor tyrosine kinase. The author has an hindex of 8, co-authored 9 publications receiving 1549 citations.
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Journal ArticleDOI
Targeting HER2-Positive Breast Cancer with Trastuzumab-DM1, an Antibody–Cytotoxic Drug Conjugate
Gail Lewis Phillips,Guangmin Li,Debra L. Dugger,Lisa Crocker,Kathryn Parsons,Elaine Mai,Walter A. Blattler,John M. Lambert,Ravi V. J. Chari,Robert J. Lutz,Wai Lee T. Wong,Frederic S. Jacobson,Hartmut Koeppen,Ralph H. Schwall,Sara R. Kenkare-Mitra,Susan D. Spencer,Mark X. Sliwkowski +16 more
TL;DR: In vitro and in vivo efficacy, pharmacokinetics, and toxicity of trastuzumab-maytansinoid (microtubule-depolymerizing agents) conjugates using disulfide and thioether linkers are determined andtrastuzuab-MCC-DM1 shows greater activity compared with nonconjugated trastumab while maintaining selectivity for HER2-overexpressing tumor cells.
Journal ArticleDOI
Analysis of heregulin-induced ErbB2 phosphorylation with a high-throughput Kinase receptor activation enzyme-linked immunosorbant assay.
Michael D. Sadick,Mark X. Sliwkowski,Andrew Nuijens,Laura N. Bald,Nan Chiang,Julie A. Lofgren,Wai Lee T. Wong +6 more
TL;DR: A rapid, sensitive, and high-throughput assay has been developed to quantify ligand-induced receptor tyrosine kinase activation in terms of receptor phosphorylation of ErbB2 that results from the interaction of HRG withErbB3 and/or Erbb4.
Journal Article
Activin A and activin B measured in maternal serum, cord blood serum andamniotic fluid during human pregnancy
Felice Petraglia,S Garg,P Florio,M Sadick,Andrea Gallinelli,Wai Lee T. Wong,Lynne A. Krummen,G Comitini,Jennie P. Mather,Teresa K. Woodruff +9 more
Journal ArticleDOI
Monoclonal antibody based ELISAs for measurement of activins in biological fluids
TL;DR: A reliable, convenient and rapid MAb-based enzyme immunoassay for determination of activin A and B levels in human serum which is also applicable for buffer, mouse and monkey serum matrices is developed.
Journal ArticleDOI
Analysis of Neurotrophin/Receptor Interactions with a gD-Flag-Modified Quantitative Kinase Receptor Activation (gD.KIRA) Enzyme-Linked Immunosorbent Assay
Michael D. Sadick,Amy Galloway,David L. Shelton,Victoria Hale,Suzanne Weck,Vince Anicetti,Wai Lee T. Wong +6 more
TL;DR: The capacity of the assay to quantify ligand bioactivity compared well with the more widely used radioreceptor binding and PC 12 cell survival assays and the assay agreed well with currently existing ELISA assays.