W
Wai Mun Huang
Researcher at University of Utah
Publications - 58
Citations - 6713
Wai Mun Huang is an academic researcher from University of Utah. The author has contributed to research in topics: Gene & DNA. The author has an hindex of 35, co-authored 58 publications receiving 6451 citations. Previous affiliations of Wai Mun Huang include Albert Einstein College of Medicine & Rocky Mountain Laboratories.
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Journal ArticleDOI
Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi
Claire M. Fraser,Sherwood R. Casjens,Wai Mun Huang,Granger G. Sutton,Rebecca A. Clayton,Raju Lathigra,Owen White,Karen A. Ketchum,Robert J. Dodson,Erin Hickey,Michelle L. Gwinn,Brian Dougherty,J F Tomb,Robert D. Fleischmann,Delwood Richardson,Jeremy Peterson,Anthony R. Kerlavage,John Quackenbush,Steven L. Salzberg,Mark S. Hanson,René Van Vugt,Nanette Palmer,Mark Raymond Adams,Jeannine D. Gocayne,Janice Weidman,Teresa Utterback,Larry Watthey,Lisa McDonald,Patricia Artiach,Cheryl Bowman,Stacey Garland,Claire Fujii,Matthew D. Cotton,Kurt Horst,Kevin Roberts,Bonnie Hatch,Hamilton O. Smith,J. Craig Venter +37 more
TL;DR: The genome of the bacterium Borrelia burgdorferi B31, the aetiologic agent of Lyme disease, contains a linear chromosome of 910,725 base pairs and at least 17 linear and circular plasmids with a combined size of more than 533,000 base pairs, which suggest their limited metabolic capacities reflect convergent evolution by gene loss from more metabolically competent progenitors.
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A bacterial genome in flux: the twelve linear and nine circular extrachromosomal DNAs in an infectious isolate of the Lyme disease spirochete Borrelia burgdorferi.
Sherwood R. Casjens,Nanette Palmer,René Van Vugt,Wai Mun Huang,Brian Stevenson,Patricia A. Rosa,Raju Lathigra,Granger G. Sutton,Jeremy Peterson,Robert J. Dodson,Daniel H. Haft,Erin Hickey,Michelle L. Gwinn,Owen White,Claire M. Fraser +14 more
TL;DR: It is determined that Borrelia burgdorferi strain B31 MI carries 21 extrachromosomal DNA elements, the largest number known for any bacterium, and the nucleotide sequence of three linear and seven circular plasmids in this infectious isolate is reported.
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Cloning and nucleotide sequence of Mycobacterium tuberculosis gyrA and gyrB genes and detection of quinolone resistance mutations.
Howard Takiff,L. Salazar,C. Guerrero,Wolfgang J. Philipp,Wai Mun Huang,Barry N. Kreiswirth,Stewart T. Cole,William R. Jacobs,Amalio Telenti +8 more
TL;DR: The cloned and sequenced wild-type gyrA and gyrB genes will facilitate analysis of the mechanisms of resistance to drugs which target the gyrase and the implementation of rapid strategies for the estimation of FQ susceptibility in clinical M. tuberculosis isolates.
Journal ArticleDOI
Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations.
TL;DR: The gyrA gene of Campylobacter jejuni UA580, which encodes the A subunit of DNA gyrase, was cloned and its nucleotide sequence was determined, which could code for a polypeptide of 863 amino acids with a M(r) of 97 kDa.
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Neisseria gonorrhoeae acquires mutations in analogous regions of gyrA and parC in fluoroquinolone‐resistant isolates
TL;DR: The frequencies of transformation, resulting in different levels of ciprofloxacin resistance, further support the notion that both gyrA and parC genes are invoived in the establishment of extreme levels ofciproFLoxac in N. gonorrhoeae.