Brian Stevenson

TL;DR: It is determined that Borrelia burgdorferi strain B31 MI carries 21 extrachromosomal DNA elements, the largest number known for any bacterium, and the nucleotide sequence of three linear and seven circular plasmids in this infectious isolate is reported.

TL;DR: This Review integrates a large body of information on the phylogenetic diversity, molecular biology, genetics and host interactions of B. burgdorferi into a cohesive picture of the molecular and cellular events that transpire as Lyme disease spirochaetes transit between their arthropod and vertebrate hosts during the enzootic cycle.

TL;DR: Exome sequencing detected somatic mutations in protein-coding regions in seven melanoma cell lines and donor-matched germline cells, which showed the hallmark of UV-induced DNA repair, but such a hallmark was absent in tumor sample–specific mutations in two metastases derived from the same individual.

TL;DR: Immunoblotting of bacterial lysates with sera from infected mice indicated that the levels of several additional antigens were also increased in bacterial cultures shifted to 35 degrees C; one antigen was identified as OspE, which has been proposed to be coexpressed in an operon with the gene encoding OSpE.

TL;DR: A comprehensive genome-wide survey of expression for a set of 153 previously described cancer/Testis CT genes in normal and cancer expression libraries finds that although they are generally highly expressed in testis, these genes exhibit heterogeneous gene expression profiles, allowing their classification into testis- restricted, testis/brain-restricted, and a testi-selective group of genes that show additional expression in somatic tissues.