Waleed O. Twal

TL;DR: The findings support the possibility that LRP-2 can act in vivo to mediate clearance of the complex from biological fluids such as cerebrospinal fluid and thereby play a role in the regulation of Abeta accumulation and indicate that apoJ facilitates Abeta1-40 binding to L RP-2 and that the receptor mediates cellular clearance of Abetas 1-40-apoJ complex leading to lysosomal degradation.

TL;DR: In this paper, the authors extend the widely used cellular Potts model to include active cell motility and assume a positive feedback between cell displacements and cell polarity, and the resulting model is studied with computer simulations and is shown to exhibit behavior compatible with experimental findings.

TL;DR: A role for this receptors for cubilin is suggested in embryonic acquisition of maternal HDL and renal catabolism of filterable forms of HDL, based on findings of yolk-sac endoderm-like cells used to identify an endocytic receptor for HDL.

TL;DR: Fibulin-1 was found to inhibit extracellular signal regulated kinase (ERK) activation and to suppress phosphorylation of myosin heavy chain, suggesting that the motility-suppressive effects of fibulin- 1 might be FN specific.

TL;DR: The findings indicate that HDL has endothelial barrier promoting activities, which are attributable to its S1P component and signaling through the S 1P1/Akt pathway.