Walker T. McGraw

TL;DR: It is proposed that PAD, acting in concert with arginine-specific proteinases from P. gingivalis, promotes the growth of the pathogen in the periodontal pocket, initially by enhancing its survivability and then by assisting the organism in its circumvention of host humoral defenses.

TL;DR: Two proteinases with arginine and lysine specificity were isolated from a high molecular mass fraction of the P. gingivalis culture fluid and Lys-gingipain was found to be a cysteine proteinase with optimal activity and stability at pH 8.0-8.5 and was extensively characterized in terms of its specificity and activation characteristics.

TL;DR: With specific proteinase inhibitors, it was shown that hemagglutination by either proteinase-adhesin complex could occur independently of proteinase activity, indicating that adherence to these proteins and not the hemagGLutination activity was a primary property of the adhesin activity component of complexes.

TL;DR: It is shown here that conditioned medium of MP24.15 antisense-transfected SKNMC neuroblastoma has significantly higher levels of Aβ, and pharmacological modulation of either enzyme may provide a means of regulating Aβ in the brain.

TL;DR: The results support the proposal that antithrombin circulates in a constrained conformation, which when released, in this study by perturbation of the bonding of P1 Arg to the body of the molecule, allows the reactive site loop to take up the active inhibitory conformation with exposure of the P1Arg.