Flow chemistry involves the use of channels or tubing to conduct a reaction in a continuous stream rather than in a flask Flow equipment provides chemists with unique control over reaction parameters enhancing reactivity or in some cases enabling new reactions This relatively young technology has received a remarkable amount of attention in the past decade with many reports on what can be done in flow Until recently, however, the question, “Should we do this in flow?” has merely been an afterthought This review introduces readers to the basic principles and fundamentals of flow chemistry and critically discusses recent flow chemistry accounts

The Hitchhiker's Guide to Flow Chemistry

Biological and Phytochemical Screening of Plants

Differential spectrophotometry of purine compounds by means of specific enzymes; determination of hydroxypurine compounds.

Über einige neue charakteristische Farbreaktionen der Thymonukleïnsäure und eine Mikromethode zur Bestimmung derselben in tierischen Organen mit Hilfe dieser Reaktionen

3.1. Chelation 564 3.2. Acid−Base Character 564 3.3. Photochemistry 565 4. In Vitro Antimicrobial Spectra 566 5. Structure−Activity Relationships 568 5.1. N-1 Ethyl Family 568 5.2. N-1 Cyclopropyl Family 568 5.3. N-1 to C-8 Bridged (Tricyclic) Family 568 5.4. N-1 Aryl Family 569 5.5. Positions C-2, C-3, and C-4 570 5.6. C-4a Substituted Analogues 571 5.7. C-5 Substituents 571 5.8. C-6 Substituents 571 5.9. C-7 Substituents 571 5.9.1. Piperazinyl and Related Moieties 572 5.9.2. Pyrrolidinyl and Related Moieties 572 5.9.3. Cyclobutylaminyl and Related Moieties 572 5.9.4. Bicycloaminyl Moieties 572 5.9.5. Carbon-Linked Substituents 572 5.10. Substituents at C-8 573 5.11. Resume of Structure−Activity Relationships of Quinolones 573

Bacterial topoisomerase inhibitors: quinolone and pyridone antibacterial agents.

The Synthesis of Certain Substituted Quinolines and 5,6-Benzoquinolines

By the addition of substituted benzyl halides to hexamethylenetetramine, a series of quaternary salts of this base was obtained. These salts represent a new group of organic bactericides. The results obtained in the tests with these substances upon Bacillus typhosus have demonstrated the existence of direct relationships between chemical constitution and bactericidal action within the series. The bactericidal character is directly attributable to the presence of the hexamethylenetetramine nucleus. The degree of the bactericidal action, however, is determined by the position, character, and number of the groups substituted in the benzene nucleus. By the introduction of the methyl, chlorine, bromine, iodine, cyano, and nitro groups into the benzene nucleus of the parent benzyl hexamethylenetetraminium salt, the bactericidal power of this compound was notably enhanced. The substitution of these groups in the ortho position almost invariably resulted in substances which were more active than their meta or para isomers. The introduction of the methoxy group was without marked effect. Several substances in which two hexamethylenetetraminium side-chains occurred were found to be the most active of the substances of this series when tested against Bacillus typhosus. Comparative tests with other bacterial types demonstrated that these compounds possessed a marked degree of specificity for Bacillus typhosus.

/pdf/the-bactericidal-properties-of-the-quaternary-salts-of-51lf3t0olp.pdf

The bactericidal properties of the quaternary salts of hexamethylenetetramine i. the problem of the chemotherapy of experimental bacterial infections.

The extension of the study of the quaternary salts of hexamethylenetetramine to those obtained by the addition of this base to the most varied types of substances containing aliphatically bound halogen has demonstrated that the introduction of the hexamethylenetetramine nucleus in this manner results in the production of bactericidal substances or enhances the bactericidal action if already present. In particular it was found possible by the use of the halogenacetyl group, XCH(2)CO, as a connecting link, to furnish primary and secondary aliphatic and aromatic amines, alcohols, and hydrocarbons of the most varied character with the hexamethylenetetramine molecule and to study the relation between chemical constitution and bactericidal action in the series of substances so prepared. Because of the variety of chemical types studied, the results are too involved for a detailed summary here. Many of the substances were found to be very powerful bactericides, and in a number of instances derivatives of purely aliphatic nature were found to possess an unusual bactericidal power. Bacillus typhosus, streptococcus, meningococcus, and gonococcus were the microorganisms used for the tests, and striking instances of partial specificity were observed. This specificity was found to favor not one species alone, but instances were found in which each of the types of bacilli was shown to be especially susceptible to one or another of the particular types of compound employed. The source of this partial specificity is to be sought not in the hexamethylenetetramine nucleus itself but in the molecule to which it is attached. The action of some of the substances was tested in the presence of serum or protein and was found to be not at all or only slightly inhibited. In other cases marked inhibition occurred. The factors controlling the serum- or protein-compatibility of these substances are likewise to be sought in that portion of the molecule other than the hexamethylenetetramine.

https://rupress.org/jem/article-pdf/23/5/577/1174026/577.pdf

The bactericidal properties of the quaternary salts of hexamethylenetetramine : iii. the relation between constitution and bactericidal action in the quaternary salts obtained from halogenacetyl compounds.

Walter A. Jacobs

Papers

The Synthesis of Certain Substituted Quinolines and 5,6-Benzoquinolines

The bactericidal properties of the quaternary salts of hexamethylenetetramine i. the problem of the chemotherapy of experimental bacterial infections.

The bactericidal properties of the quaternary salts of hexamethylenetetramine : iii. the relation between constitution and bactericidal action in the quaternary salts obtained from halogenacetyl compounds.

The ergot alkaloids viii. the synthesis of 4-carboline carbonic acids

THE ERGOT ALKALOIDS. XX. THE SYNTHESIS OF DIHYDRO-dl-LYSERGIC ACID. A NEW SYNTHESIS OF 3-SUBSTITUTED QUINOLINES