Walter Schubert

TL;DR: By analyzing many cell and tissue types, this approach reveals rules of hierarchical protein network organization, in which the frequency distribution of different protein clusters obeys Zipf's law, and state-specific lead proteins appear to control protein network topology and function.

TL;DR: A preferential localization of APP is reported at synaptic sites of human and rat brain and at neuromuscular junctions, implying a role of APP in physiological synaptic activity and a potential and early impairment of central synapses when synaptic APP is converted to beta A4 amyloid during the pathological evolution of Alzheimer's disease and Down's syndrome.

TL;DR: The results support the viewpoint that an oxygen radical-induced impairment of mtDNA is of pathophysiological significance in the aetiology of at least a subgroup of patients with SALS.

TL;DR: It is reported that monoclonal antibody Leu-19 (mAb-Leu19) labels structures in human skeletal muscle: satellite cells, which form the stem cell pool of muscle fiber regeneration, both in normal and diseased muscle; myotubes and myotube projections in regions of Muscle fiber repair; periodically organized fibrillar structures in areas of regeneration.

TL;DR: The localization of APP at synaptic sites in brain suggests that APP regulation and expression are critical determinants of a potential and early impairment of central synapses.