W
Walter Wolf
Researcher at University of Southern California
Publications - 93
Citations - 1947
Walter Wolf is an academic researcher from University of Southern California. The author has contributed to research in topics: Pharmacokinetics & Radical. The author has an hindex of 24, co-authored 93 publications receiving 1902 citations. Previous affiliations of Walter Wolf include United States Department of Veterans Affairs & National Autonomous University of Mexico.
Papers
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Journal ArticleDOI
Tumor trapping of 5-fluorouracil: in vivo 19F NMR spectroscopic pharmacokinetics in tumor-bearing humans and rabbits
Walter Wolf,C A Presant,K L Servis,A el-Tahtawy,M J Albright,P B Barker,rd R Ring,Dennis J. Atkinson,R L Ong,M King +9 more
TL;DR: These studies document that NMR spectroscopy is clinically feasible in vivo, allows noninvasive pharmacokinetic analyses at a drug-target tissue in real time, and may produce therapeutically important information at the time of drug administration.
Journal ArticleDOI
Fluorine-19 NMR spectroscopic studies of the metabolism of 5-fluorouracil in the liver of patients undergoing chemotherapy
TL;DR: These observations represent the first noninvasive NMR study of drugs in human patients and show the feasibility of using in vivo F-19 NMR spectroscopy for human studies of fluorinated compounds.
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19F-MRS studies of fluorinated drugs in humans
TL;DR: The use of 19F-NMR as a noninvasive probe to measure directly the pharmacokinetics of drugs at their target (effector) site(s) is illustrated in this article by human studies with 5-fluorouracil and other fluoropyrimidines.
Journal Article
Radiogallium Localization in Tumors: Blood Binding and Transport and the Role of Transferrin
TL;DR: It is demonstrated that gallium at the tracer level in blood is exclusively bound to and transported by transferrin, and indicates that electrophoresis and dialysis of easily dissociable metal complexes are subject to significant artifacts.
Journal ArticleDOI
Human tumor fluorouracil trapping: clinical correlations of in vivo 19F nuclear magnetic resonance spectroscopy pharmacokinetics.
Cary A. Presant,Walter Wolf,M J Albright,K L Servis,R Ring,Dennis J. Atkinson,R L Ong,Charles L. Wiseman,M King,Douglas W. Blayney +9 more
TL;DR: Evaluating the pharmacokinetics of 5FU in the tumors of 11 patients with carcinoma of the breast, colon, endometrium, cervix, and kidney using 19F-NMRS concludes that NMRS is clinically feasible, and enables investigators to study 5FU pharmacokinetic and metabolism in tumors in vivo.