W
Wanda S. LeJeune
Researcher at University of Texas Medical Branch
Publications - 19
Citations - 1497
Wanda S. LeJeune is an academic researcher from University of Texas Medical Branch. The author has contributed to research in topics: Proinflammatory cytokine & Hemodynamics. The author has an hindex of 16, co-authored 19 publications receiving 1360 citations. Previous affiliations of Wanda S. LeJeune include Washington University in St. Louis.
Papers
More filters
Journal ArticleDOI
An adventitial IL-6/MCP1 amplification loop accelerates macrophage-mediated vascular inflammation leading to aortic dissection in mice
Brian C. Tieu,Chang Lee,Hong Sun,Wanda S. LeJeune,Adrian Recinos,Xiaoxi Ju,Heidi Spratt,Dongchuan Guo,Dianna M. Milewicz,Ronald G. Tilton,Allan R. Brasier +10 more
TL;DR: Results suggest that leukocyte-fibroblast interactions in the aortic adventitia potentiate IL-6 production, inducing local monocyte recruitment and activation, thereby promoting MCP-1 secretion, vascular inflammation, ECM remodeling, and aortIC destabilization.
Journal ArticleDOI
Klotho depletion contributes to increased inflammation in kidney of the db/db mouse model of diabetes via RelA (serine)536 phosphorylation.
Yanhua Zhao,Srijita Banerjee,Nilay Dey,Wanda S. LeJeune,Partha S. Sarkar,Reynolds Brobey,Kevin P. Rosenblatt,Ronald G. Tilton,Sanjeev Choudhary +8 more
TL;DR: Findings suggest that Klotho serves as an anti-inflammatory modulator, negatively regulating the production of NF-κB–linked inflammatory proteins via a mechanism that involves phosphorylation of Ser536 in the transactivation domain of RelA.
Journal Article
Role for nitric oxide in the hyperpermeability and hemodynamic changes induced by intravenous VEGF.
Ronald G. Tilton,Katherine Chang,Wanda S. LeJeune,Clifford Stephan,Tommy A. Brock,Joseph R. Williamson +5 more
TL;DR: Intravenous infusion of VEGF can acutely impair endothelial cell barrier functional integrity and relax resistance arterioles in ocular tissues and brain through a mechanism involving activation of NOS.
Journal ArticleDOI
Angiotensin II induces IL-6 expression and the Jak-STAT3 pathway in aortic adventitia of LDL receptor-deficient mice
Adrian Recinos,Wanda S. LeJeune,Hong Sun,Chang Lee,Brian C. Tieu,Muping Lu,Tieying Hou,Istvan Boldogh,Ronald G. Tilton,Allan R. Brasier +9 more
TL;DR: It is demonstrated that IL-6, produced by activated macrophages and fibroblasts in the adventitia, induces the Jak-STAT3 pathway during early A-II-induced atherosclerosis.
Journal ArticleDOI
Interleukin-6–Signal Transducer and Activator of Transcription-3 Signaling Mediates Aortic Dissections Induced by Angiotensin II via the T-Helper Lymphocyte 17–Interleukin 17 Axis in C57BL/6 Mice
Xiaoxi Ju,Talha Ijaz,Hong Sun,Sutapa Ray,Wanda S. LeJeune,Chang Lee,Adrian Recinos,Dongchuan Guo,Dianna M. Milewicz,Ronald G. Tilton,Allan R. Brasier +10 more
TL;DR: The results indicate that the IL-6–signal transducer and activator of transcription-3 signaling pathway converges on Th17 recruitment and IL-17A signaling upstream of macrophage recruitment, mediating aortic dissections.