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Wangchen Tsering
Researcher at University of Pennsylvania
Publications - 5
Citations - 49
Wangchen Tsering is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Genetically modified mouse & Allele. The author has an hindex of 2, co-authored 3 publications receiving 15 citations. Previous affiliations of Wangchen Tsering include Earlham College.
Papers
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Journal ArticleDOI
Neurocognitive Functioning in Patients with 22q11.2 Deletion Syndrome: A Meta-Analytic Review
Paul J. Moberg,Paul J. Moberg,Mara J. Richman,Mara J. Richman,David R. Roalf,Chelsea L. Morse,Chelsea L. Morse,Anna C. Graefe,Anna C. Graefe,Laura Brennan,Laura Brennan,Kayci L Vickers,Kayci L Vickers,Wangchen Tsering,Wangchen Tsering,Vidyulata Kamath,Vidyulata Kamath,Bruce I. Turetsky,Ruben C. Gur,Ruben C. Gur,Raquel E. Gur,Raquel E. Gur +21 more
TL;DR: Large cognitive deficits in intellectual functioning and specific neuropsychological variables in individuals with 22q11.2DS represent a robust finding, but these deficits are influenced by several factors, including type of comparison group utilized, age, sex, and clinical status.
Journal ArticleDOI
Effects of microglial depletion and TREM2 deficiency on Aβ plaque burden and neuritic plaque tau pathology in 5XFAD mice.
Argyro Thalia Delizannis,Annelies Nonneman,Wangchen Tsering,An De Bondt,Ilse Van den Wyngaert,Bin Zhang,Emily S. Meymand,Modupe F. Olufemi,Pyry Koivula,Shaniya Maimaiti,John Q. Trojanowski,Virginia M.-Y. Lee,Kurt R. Brunden +12 more
TL;DR: Zhang et al. as mentioned in this paper investigated the role of Aβ plaque-associated microglia in 5XFAD mice in which NP tau pathology forms after intracerebral injection of AD brain-derived pathologic tau (AD-tau), focusing on the consequences of reduced TREM2 expression and microglial depletion after treatment with the colony-stimulating factor 1 (CSFR1) inhibitor, PLX3397.
Journal ArticleDOI
Correction of microtubule defects within Aβ plaque-associated dystrophic axons results in lowered Aβ release and plaque deposition
Yuemang Yao,Goodwell Nzou,Thibault Alle,Wangchen Tsering,Shaniya Maimaiti,John Q. Trojanowski,Virginia M.-Y. Lee,Carlo Ballatore,Kurt R. Brunden +8 more
TL;DR: A vicious cycle whereby initial Aβ plaque formation causes MT disruption in nearby axons, resulting in the local accumulation of APP and BACE1 that facilitates additional Aβ generation and plaque deposition is suggested.
Journal ArticleDOI
Impact of APOE genotype on prion-type propagation of tauopathy
Tristan Williams,Alejandra Jolie Ruiz,Angelica Maria Ruiz,Quan Vo,Wangchen Tsering,Guilian Xu,Karen N. McFarland,Benoit I. Giasson,Patrick Sullivan,David R. Borchelt,Paramita Chakrabarty +10 more
TL;DR: In this paper , the effects of Apolipoprotein (APOE) isoforms on tau pathology were investigated in mouse transgenic mice with either human APOE (APO2, APOE3 or APOE4) or mouse Apoe allele.
Journal ArticleDOI
Impact of APOE genotype on prion-type propagation of tauopathy
Tristan Williams,Alejandra Jolie Ruiz,Angelica Maria Ruiz,Quan Vo,Wangchen Tsering,Guilian Xu,Karen N. McFarland,Benoit I. Giasson,Patrick Sullivan,David R. Borchelt,Paramita Chakrabarty +10 more
TL;DR: In this paper , the effects of Apolipoprotein (APOE) isoforms on tau pathology were investigated in mouse transgenic mice with either human APOE (APO2, APOE3 or APOE4) or mouse Apoe allele.