Y
Yuemang Yao
Researcher at University of Pennsylvania
Publications - 38
Citations - 2784
Yuemang Yao is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Oxidative stress & Tau protein. The author has an hindex of 26, co-authored 37 publications receiving 2520 citations.
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Journal ArticleDOI
The Microtubule-Stabilizing Agent, Epothilone D, Reduces Axonal Dysfunction, Neurotoxicity, Cognitive Deficits, and Alzheimer-Like Pathology in an Interventional Study with Aged Tau Transgenic Mice
Bin Zhang,Jenna C. Carroll,John Q. Trojanowski,Yuemang Yao,Michiyo Iba,Justin S. Potuzak,Anne-Marie L. Hogan,Sharon X. Xie,Carlo Ballatore,Amos B. Smith,Virginia M.-Y. Lee,Kurt R. Brunden +11 more
TL;DR: Data reveal that brain-penetrant MT-stabilizing drugs hold promise for the treatment of AD and related tauopathies, and that EpoD could be a candidate for clinical testing.
Journal ArticleDOI
Early vitamin E supplementation in young but not aged mice reduces Aβ levels and amyloid deposition in a transgenic model of Alzheimer’s disease
Syuan Sung,Yuemang Yao,Kunihiro Uryu,Hengxuan Yang,Virginia M.-Y. Lee,John Q. Trojanowski,Domenico Praticò +6 more
TL;DR: The hypothesis that oxidative stress is an important early event in AD pathogenesis, and antioxidant therapy may be beneficial only if given at this stage of the disease process is supported.
Journal ArticleDOI
Epothilone D Improves Microtubule Density, Axonal Integrity, and Cognition in a Transgenic Mouse Model of Tauopathy
Kurt R. Brunden,Bin Zhang,Jenna C. Carroll,Yuemang Yao,Justin S. Potuzak,Anne-Marie L. Hogan,Michiyo Iba,Michael J. James,Sharon X. Xie,Carlo Ballatore,Amos B. Smith,Virginia M.-Y. Lee,John Q. Trojanowski +12 more
TL;DR: Treatment of 3-month-old male PS19 mice with low doses of EpoD once weekly for a 3 month period significantly improved CNS MT density and axonal integrity without inducing notable side-effects, suggesting that certain brain-penetrant MT-stabilizing agents might provide a viable therapeutic strategy for the treatment of AD and FTDs.
Journal ArticleDOI
12/15-Lipoxygenase Is Increased in Alzheimer's Disease: Possible Involvement in Brain Oxidative Stress
Domenico Praticò,Victoria Zhukareva,Yuemang Yao,Kunihiro Uryu,Colin D. Funk,John A. Lawson,John Q. Trojanowski,Virginia M.-Y. Lee +7 more
TL;DR: In this paper, the authors investigated the protein levels and activity of 12/15-LOX in different brain regions of histopathologically confirmed Alzheimer's disease and control cases, using quantitative Western blot analysis.
Journal ArticleDOI
Vitamin E reduces amyloidosis and improves cognitive function in Tg2576 mice following repetitive concussive brain injury
Valeria Conte,Kunihiro Uryu,Scott Fujimoto,Scott Fujimoto,Yuemang Yao,Joshua Rokach,Luca Longhi,Luca Longhi,John Q. Trojanowski,Virginia M.-Y. Lee,Tracy K. McIntosh,Tracy K. McIntosh,Domenico Praticò +12 more
TL;DR: It is suggested that the exacerbation of brain oxidative stress following RCBI plays a mechanistic role in accelerating Αβ accumulation and behavioral impairments in the Tg2576 mice.