W
Wanjiang Zhang
Researcher at Washington University in St. Louis
Publications - 4
Citations - 486
Wanjiang Zhang is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Presenilin & Membrane protein. The author has an hindex of 4, co-authored 4 publications receiving 477 citations.
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Journal ArticleDOI
Evidence for a physical interaction between presenilin and Notch.
William J. Ray,Min Yao,Petra Nowotny,Jeff S. Mumm,Wanjiang Zhang,Jane Y. Wu,Raphael Kopan,Alison Goate +7 more
TL;DR: The results suggest that the genetic relationship between presenilins and the Notch signaling pathway derives from a direct physical association between these proteins in the secretory pathway.
Journal ArticleDOI
Regulation of Ich-1 pre-mRNA alternative splicing and apoptosis by mammalian splicing factors
TL;DR: Results provide the first direct evidence that splicing factors can regulate Ich-1 alternative splicing and suggest thatAlternative splicing may be an important regulatory mechanism for apoptosis.
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Interaction of Presenilins with the Filamin Family of Actin-Binding Proteins
TL;DR: It is reported here that the loop regions of PS1 and PS2 interact with nonmuscle filamin and a structurally related protein (filamin homolog 1, Fh1) and that interactions between presenilins and ABP280/Fh1 may be functionally significant.
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Presenilin-1 protects against neuronal apoptosis caused by its interacting protein PAG.
Yan Zhou,Wanjiang Zhang,Rachael M. Easton,James W. Ray,Patricia A. Lampe,Zhihong Jiang,Anne L. Brunkan,Alison Goate,Eugene M. Johnson,Jane Y. Wu +9 more
TL;DR: It is reported here that the proliferation-associated gene (PAG) product, a protein of the thioredoxin peroxidase family, interacts with PS-1, and a neuroprotective activity of the wild-typePS-1 is demonstrated, suggesting possible involvement of defective neuroprotection by PS- 1 mutants in neurodegeneration.