W
William J. Ray
Researcher at University of Texas MD Anderson Cancer Center
Publications - 156
Citations - 13724
William J. Ray is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Allosteric regulation & Amyloid precursor protein. The author has an hindex of 53, co-authored 154 publications receiving 12885 citations. Previous affiliations of William J. Ray include Merck & Co. & University of Utah.
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Journal ArticleDOI
A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain.
Bart De Strooper,Wim Annaert,Philippe Cupers,Paul Saftig,Katleen Craessaerts,Jeff S. Mumm,Eric H. Schroeter,Vincent Schrijvers,Michael S. Wolfe,William J. Ray,Alison Goate,Raphael Kopan +11 more
TL;DR: It is reported that, in mammalian cells, PS1 deficiency also reduces the proteolytic release of NICD from a truncated Notch construct, thus identifying the specific biochemical step of the Notch signalling pathway that is affected by PS1.
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EEG alpha activity reflects attentional demands, and beta activity reflects emotional and cognitive processes
William J. Ray,Harry W. Cole +1 more
TL;DR: An interaction of task with hemisphere as well as more overall parietal alpha for tasks not requiring attention to the environment, such as mental arithmetic, than for those requiring such attention.
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A ligand-induced extracellular cleavage regulates γ-secretase-like proteolytic activation of Notch1
Jeff S. Mumm,Eric H. Schroeter,Meera T. Saxena,Adam Griesemer,Xiaolin Tian,Duojia Pan,William J. Ray,Raphael Kopan +7 more
TL;DR: It is demonstrated that ligand binding facilitates cleavage at a novel site (S2), within the extracellular juxtamembrane region, which serves to release ectodomain repression of NICD production.
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Worry: A cognitive phenomenon intimately linked to affective, physiological, and interpersonal behavioral processes.
TL;DR: Worry involves a predominance of verbal thought activity, functions as a type of cognitive avoidance, and inhibits emotional processing as discussed by the authors, and also produces not only anxious experience but depressive affect as well.
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Chaos and physiology: deterministic chaos in excitable cell assemblies
Thomas Elbert,William J. Ray,Zbigniew J. Kowalik,James E. Skinner,Karl Eugen Graf,Niels Birbaumer +5 more
TL;DR: This review examined the emerging science of deterministic chaos (nonlinear systems theory) and its application to selected physiological systems and to the neurosciences, demonstrating that the dynamics of neural mass activity reflect psychopathological states.