Wei Chen

TL;DR: It is demonstrated that targeted disruption of Atp6i in mice results in severe osteopetrosis and is unique and necessary for osteoclast-mediated extracellular acidification.

TL;DR: TGF-β blockade improved the intratumoral penetration of both a low-molecular-weight conventional chemotherapeutic drug and a nanotherape therapeutic agent, leading to better control of tumor growth.

TL;DR: It is suggested that yeast cells contain multiple proteins with distinct sequence specificities that carry out a related "TATA function" and that yeast promoters can be divided into classes based on their downstream promoter elements.

TL;DR: This review discusses how Wnt ligands, receptors, intracellular effectors, transcription factors, and antagonists affect both the bone modeling and bone remodeling processes and describes potential therapeutic targets to treat these bone diseases.

TL;DR: This review summarizes recent advances in studies of signaling transduction pathways and transcriptional regulation of osteoblast and osteoclast cell lineage commitment and differentiation that enable a better understanding of the multiple factors and signaling networks that control the differentiation process at a molecular level.