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Wei Chen
Researcher at Tsinghua University
Publications - 6
Citations - 14
Wei Chen is an academic researcher from Tsinghua University. The author has contributed to research in topics: Medicine & Gene. The author has an hindex of 1, co-authored 3 publications receiving 3 citations.
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Journal ArticleDOI
Functional exploration of heterotrimeric kinesin-II in IFT and ciliary length control in Chlamydomonas
TL;DR: It is shown that in Chlamydomonas motors are only stable as heterodimers in vivo, which is likely the key factor for the requirement of a heterodimer for IFT.
Journal ArticleDOI
Proteomic mapping and targeting of mitotic pericentriolar material in tumors bearing centrosome amplification.
Bingteng Xie,Yang Pu,Fan Yang,Wei Chen,Wei Yue,Jihong Ma,Na Zhang,Yuening Jiang,Jiegen Wu,Yihan Lin,Xinhui Liang,Chu Wang,Peng Zou,Mo Li +13 more
TL;DR: This study suggests a strategy for targeting a wide range of tumors exhibiting centrosome amplification and provides a proteomic resource for future mining of PCM proteins in living undisturbed cells without synchronization treatment.
Journal ArticleDOI
TUBright: A Peptide Probe for Imaging Microtubules.
Songbo Xie,Jingrui Li,Shuang Sun,Wei Chen,Haisu Cheng,Yinlong Song,Yuyang Li,Min Liu,Xueliang Zhu,Xin Liang,Jun Zhou +10 more
TL;DR: TUBright, when coupled with different fluorescent dyes, provides flexible labeling of microtubules with a high signal-to-noise ratio, making it feasible to use tubulin from limited sources for answering many open questions on microtubule dynamics.
Posted ContentDOI
Functional Exploration of Heterotrimeric Kinesin-II in IFT and Ciliary Length Control in Chlamydomonas
TL;DR: Modelling analyses suggest that such a non-linear scaling relationship between IFT velocity and ciliary length can be accounted for by limitation of the motors and/or its ciliary cargoes, e.g. tubulin.
Journal ArticleDOI
The distinct initiation sites and processing activities of TTLL4 and TTLL7 in glutamylation of brain tubulin.
Xinyue Zhang,Xiangxiao Li,Wei Chen,Yujuan Wang,Lei Diao,Yan-Hong Gao,Heyi Wang,Lan Bao,Xin Liang,Hui Wu +9 more
TL;DR: In this article , an antibody-based method was used to characterize the properties of a purified recombinant TTLL4 and confirmed its sole role as an initiator, unlike TTLL7, which both initiates and elongates the side-chains.