The invention relates to a nitrogen-doped titanium oxide coating and a preparation method and application thereof. The nitrogen-doped titanium oxide coating has a porous structure, and the doping quantity of nitrogen elements is 0.5 at%-10at%.

Nitrogen-doped titanium oxide coating and preparation method and application thereof

The invention is applicable to the field of biomedical materials, and provides a method for improving the biological activity of a titanium alloy material, the titanium alloy material and application.The method comprises the following steps: preprocessing a titanium alloy material; and injecting the temperature-sensitive collagen doped with the bone morphogenetic protein 9 into pores of the preprocessed titanium alloy material, wherein the titanium alloy material is a 3D printed porous titanium alloy material. The temperature-sensitive collagen doped with the bone morphogenetic protein 9 is implanted into pores and the surface of the 3D printing porous titanium alloy material, the temperature-sensitive collagen is used as a carrier for providing controlled release of the bone morphogeneticprotein 9, the biological activity of the surface of the titanium alloy material can be enhanced, and the bone ingrowth and osseointegration capacity of the titanium alloy material can be effectivelyimproved.

Method for improving biological activity of titanium alloy material, titanium alloy material and application

The invention discloses a preparation method of a graphene oxide composited titanium-based medical material. The preparation method comprises the following steps: (1) putting graphene oxide into deionized water or ethanol, carrying out ultrasonic treatment, and carrying out freeze drying, so as to obtain graphene oxide powder; (2) carrying out ball milling on the graphene oxide powder and titanium-based powder, so as to obtain mixed powder, (3) carrying out 3D printing on the mixed powder, so as to obtain a porous composite material; (4) carrying out stress relief annealing on the porous composite material; and (5) forming micro-nano holes in the surface of the porous composite material, so as to obtain the graphene oxide composited titanium-based medical material. By introducing the graphene oxide, the excellent mechanical properties of the graphene oxide composited titanium-based medical material are guaranteed, and by forming the micro-nano holes, rapid synostosis is generated between the graphene oxide composited titanium-based medical material and peripheral bone tissues, so that the applicability of the graphene oxide composited titanium-based medical material is improved.

Preparation method of graphene oxide composited titanium-based medical material

The invention relates to a long-acting infection resisting and high-efficiency osseointegration promoting functional coating for a medical metal surface and a preparation method for the functional coating. According to the functional coating, multifunctional physiologically essential metal ions, inorganic acid radical ions and the like are subjected to ion exchange and modification with inorganicsalts on nano-fibers and the nano-pore wall of the medical metal surface; then, the medical metal surface is placed in a bionic physiological solution for a mineralization reaction; calcium phosphatecoatings similar to a bone mineral chemical composition and distributed in different granularity gradients are deposited in nano-pores, nano-fiber gaps and the upper surface of a fiber layer, and themineralized coatings effectively adjust long-acting release of the functional ions deposited on the nano-fibers, and enhances the integration efficiency and the bonding strength with bones, so that properties of long-acting infection resisting and osseointegration firming are obtained. The preparation process for the coating is simple, convenient and economical; the function of the coating is stable and has an outstanding effect, and can be suitable for surface modification of medical metal and alloy implants, which need to be permanently integrated with bones, including orthopedic implant prostheses, oral implants and the like.

Infection resisting-osseointegration promoting coating for medical metal surface, preparation method and application

The invention discloses a method for rapidly introducing function ions on the surface of titanium alloy, and belongs to the technical field of titanium alloy medical plant material surface functionalization modified treatment. The method comprises the steps that firstly, TC4 is adopted as an electrolytic anode, an electrolytic cell is adopted as an electrolytic cathode, and a volcano shaped porouscoating is formed on the surface of a TC4 sample through the plasma high temperature and high pressure transient sintering effect; then, a hydrothermal reaction method is used for introducing function ions into the coating, and meanwhile, the hydrophilicity is improved. The various function ions are evenly distributed on the surface of titanium alloy, and the adhesion and proliferation capabilityof osteogenesis cells is improved. According to the method, the coating can be prepared on the surface of the titanium alloy conveniently and rapidly, the ingredient of a solution is regulated in thefollow-up hydrothermal process, the function ions of Cu, Zn, Mg, Ce, Sr and the like are introduced to the surface of the coating, antibacterial or osteogenesis and other performances of a biologicalmedical metal material are improved, and the good application prospect is achieved in the fields of surface modification of medical implant materials and the like.

Wei Yongjie

Papers

Method for rapidly introducing function ions on surface of titanium alloy