W
Weiming Yan
Researcher at Huazhong University of Science and Technology
Publications - 17
Citations - 3474
Weiming Yan is an academic researcher from Huazhong University of Science and Technology. The author has contributed to research in topics: FGL2 & Virus. The author has an hindex of 8, co-authored 16 publications receiving 2640 citations. Previous affiliations of Weiming Yan include Tongji Medical College.
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Journal ArticleDOI
Interferon-Induced Macrophage-Derived Exosomes Mediate Antiviral Activity Against Hepatitis B Virus Through miR-574-5p.
Wen-Yu Wu,Di Wu,Weiming Yan,Yong-Li Wang,Jie You,Xiaoyang Wan,Dong Xi,Xiaoping Luo,Meifang Han,Qin Ning +9 more
TL;DR: Exosomes can transfer IFN-α-related miRNAs from macrophages to HBV-infected hepatocytes, and exhibit antiviral activities against HBV replication and expression.
Journal ArticleDOI
Dual interference with novel genes mfgl2 and mTNFR1 ameliorates murine hepatitis virus type 3-induced fulminant hepatitis in BALB/cJ mice.
Sui Gao,Ming Wang,Huali Ye,Jianwen Guo,Dong Xi,Zhi-Mo Wang,Chuanglong Zhu,Weiming Yan,Xiaoping Luo,Qin Ning +9 more
TL;DR: Results indicate that in vivo interference with genes for more than one key target provides superior treatment efficacy compared with single-gene interference.
Journal ArticleDOI
STAT1 and STAT3 α/β splice form activation predicts host responses in mouse hepatitis virus type 3 infection
Qin Ning,Lloyd Berger,Xiaoping Luo,Xiaoping Luo,Weiming Yan,Feili Gong,James W. Dennis,Gary A. Levy +7 more
TL;DR: Investigation of whether the STAT activation will predict the host immune response to viral infection and possibly a therapeutic target for the treatment of viral infection suggested that ratio of activated STAT1 α/β and STAT3 α/ β in mixed leukocytes from spleen predict the outcome to MHV‐3 infection.
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Intrahepatic recruitment of cytotoxic NK cells contributes to autoimmune hepatitis progression.
TL;DR: It is revealed that the frequency of peripheral NK cells, more accurately CD56dimNK subset, was reduced in AIH patients and the reduction was negatively correlated with disease progression.
Journal ArticleDOI
A disparate subset of double-negative T cells contributes to the outcome of murine fulminant viral hepatitis via effector molecule fibrinogen-like protein 2.
Di Wu,Hongwu Wang,Weiming Yan,Tao Chen,Ming Wang,Meifang Han,Zeguang Wu,Xiaojing Wang,Guo Ai,Dong Xi,Guanxin Shen,Xiaoping Luo,Qin Ning +12 more
TL;DR: It is demonstrated that DN T cells contribute to the outcome of MHV-3-induced FVH via an important effector molecule mfgl2, which is inhibited by a recombinant adenovirus in vivo and improved survival in mice.