W
Wen-cai Zhang
Researcher at Huazhong University of Science and Technology
Publications - 8
Citations - 475
Wen-cai Zhang is an academic researcher from Huazhong University of Science and Technology. The author has contributed to research in topics: Ventricular remodeling & Proinflammatory cytokine. The author has an hindex of 7, co-authored 8 publications receiving 391 citations. Previous affiliations of Wen-cai Zhang include Chinese Ministry of Education.
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Journal ArticleDOI
Regulatory T cells ameliorate cardiac remodeling after myocardial infarction
Tingting Tang,Jing Yuan,Zhengfeng Zhu,Wen-cai Zhang,Hong Xiao,Ni Xia,Xin-Xin Yan,Shaofang Nie,Juan Liu,Su-Feng Zhou,Jing Jing Li,Rui Yao,Mengyang Liao,Xin Tu,Yuhua Liao,Xiang Cheng +15 more
TL;DR: Data demonstrate that Treg cells serve to protect against adverse ventricular remodeling and contribute to improve cardiac function after myocardial infarction via inhibition of inflammation and direct protection of cardiomyocytes.
Journal ArticleDOI
IL-17A promotes ventricular remodeling after myocardial infarction.
Su Feng Zhou,Su Feng Zhou,Jing Yuan,Jing Yuan,Meng Yang Liao,Meng Yang Liao,Ni Xia,Ni Xia,Tingting Tang,Tingting Tang,Jing Jing Li,Jing Jing Li,Jiao Jiao,Jiao Jiao,Wen Yong Dong,Wen Yong Dong,Shao Fang Nie,Shao Fang Nie,Zheng Feng Zhu,Zheng Feng Zhu,Wen-cai Zhang,Wen-cai Zhang,Bing Jie Lv,Bing Jie Lv,Hong Xiao,Qing Wang,Qing Wang,Xin Tu,Yuhua Liao,Yuhua Liao,Guo-Ping Shi,Xiang Cheng,Xiang Cheng +32 more
TL;DR: Data demonstrate that IL-17A induces cardiomyocyte apoptosis through the p38 mitogen-activated protein kinase (MAPK)-p53-Bax signaling pathway and promotes both early- and late-phase post-MI ventricular remodeling.
Journal ArticleDOI
IL-9 aggravates the development of atherosclerosis in ApoE-/- mice.
Wen-cai Zhang,Tingting Tang,Tingting Tang,Daan Nie,Daan Nie,Shuang Wen,Shuang Wen,Chenping Jia,Chenping Jia,Zhengfeng Zhu,Zhengfeng Zhu,Ni Xia,Ni Xia,Shaofang Nie,Shaofang Nie,Su-Feng Zhou,Su-Feng Zhou,Jiao Jiao,Jiao Jiao,Wenyong Dong,Wenyong Dong,Bingjie Lv,Bingjie Lv,Tongjie Xu,Bing Sun,Yuzhi Lu,Yuzhi Lu,Yuan Yuan Li,Yuan Yuan Li,Longxian Cheng,Longxian Cheng,Yuhua Liao,Yuhua Liao,Xiang Cheng,Xiang Cheng +34 more
TL;DR: It is demonstrated that IL-9 exerted pro-atherosclerotic effects in ApoE-/- mice at least partially by inducing VCAM-1 expression, which mediated inflammatory cell infiltration into atherosclerosis lesions.
Journal ArticleDOI
Impaired thymic export and increased apoptosis account for regulatory T cell defects in patients with non-ST segment elevation acute coronary syndrome.
Wen-cai Zhang,Jun Wang,Jun Wang,Yan-Wen Shu,Yan-Wen Shu,Tingting Tang,Tingting Tang,Zhengfeng Zhu,Zhengfeng Zhu,Ni Xia,Ni Xia,Shaofang Nie,Shaofang Nie,Juan Liu,Juan Liu,Su-Feng Zhou,Su-Feng Zhou,Jing Jing Li,Jing Jing Li,Hong Xiao,Jing Yuan,Jing Yuan,Mengyang Liao,Mengyang Liao,Longxian Cheng,Longxian Cheng,Yuhua Liao,Yuhua Liao,Xiang Cheng,Xiang Cheng +29 more
TL;DR: The findings indicate that the impaired thymic output of Treg cells and their enhanced susceptibility to apoptosis in the periphery were responsible for Treg cell defects observed in the NSTACS patients.
Journal ArticleDOI
Impaired Thymic Export and Apoptosis Contribute to Regulatory T-Cell Defects in Patients with Chronic Heart Failure
Tingting Tang,Zhengfeng Zhu,Jun Wang,Wen-cai Zhang,Xin Tu,Hong Xiao,Xin-Ling Du,Jiahong Xia,Nianguo Dong,Wei Su,Ni Xia,Xing-Xing Yan,Shaofang Nie,Juan Liu,Su-Feng Zhou,Rui Yao,Jiang-jiao Xie,Harish Jevallee,Xiang Wang,Mengyang Liao,Guo-Ping Shi,Michael Fu,Yuhua Liao,Xiang Cheng +23 more
TL;DR: The data suggested that the Treg-cell defects of CHF patients were likely caused by decreased thymic output of nascent Treg cells and increased susceptibility to apoptosis in the periphery.