Wen Hua Lu

TL;DR: Results suggest that SSZ, a relatively non-toxic drug that targets cystine transporter, may, in combination with CDDP, have effective therapy for colorectal cancer.

TL;DR: It is proposed that miR-155 plays an important role in oncogenic K-Ras transformation mediated by cellular redox regulation.

TL;DR: It is reported that FLT3/ITD causes a significant increase in aerobic glycolysis through AKT-mediated upregulation of mitochondrial hexokinase (HK2), and renders the leukemia cells highly dependent on gly colysis and sensitive to pharmacological inhibition of glycoleytic activity.

TL;DR: The results showed that the expression of ACO2 was significantly down-regulated in gastric cancer tissues compared with matched adjacent non-tumorous tissues and was associated with clinical stage and patients with lower ACO1 expression had a shorter survival time.

TL;DR: This study provides a basis for developing a novel therapeutic strategy to effectively kill K-ras–transformed cells through a redox-mediated mechanism and abnormal ROS stress can selectively kill tumor cells by using NOX inhibitors.