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Wen Jing Sim

Researcher at Agency for Science, Technology and Research

Publications -  16
Citations -  961

Wen Jing Sim is an academic researcher from Agency for Science, Technology and Research. The author has contributed to research in topics: Epithelial–mesenchymal transition & Cancer. The author has an hindex of 10, co-authored 16 publications receiving 816 citations. Previous affiliations of Wen Jing Sim include National University of Singapore.

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Journal ArticleDOI

Mesenchymal Transition and Dissemination of Cancer Cells Is Driven by Myeloid-Derived Suppressor Cells Infiltrating the Primary Tumor

Benjamin Toh, +10 more
- 27 Sep 2011 - 
TL;DR: Using a spontaneous murine model of melanoma, it is shown that a subset of bone marrow-derived immune cells (myeloid-derived suppressor cells or MDSC) preferentially infiltrates the primary tumor and actively promotes cancer cell dissemination by inducing epithelial-mesenchymal transition (EMT).
Journal ArticleDOI

Screening therapeutic EMT blocking agents in a three-dimensional microenvironment

Amir Reza Aref, +11 more
- 29 Jan 2013 - 
TL;DR: A microfluidic system that integrates tumor cell spheroids in a 3D hydrogel scaffold, in close co-culture with an endothelial monolayer is presented and significant differences in response to drugs between 2D and 3D, and between monoculture and co- culture are demonstrated.

Screening therapeutic EMT blocking agents in a three-dimensional microenvironment

Amir Reza Aref, +11 more
TL;DR: Singapore National Research Foundation (Singapore MIT Alliance for Research and Technology's BioSystems and Micromechanics Inter-Disciplinary Research programme) as mentioned in this paper, Singapore.
Journal ArticleDOI

A Cell-Based Small Molecule Screening Method for Identifying Inhibitors of Epithelial-Mesenchymal Transition in Carcinoma

Kian-Ngiap Chua, +6 more
- 14 Mar 2012 - 
TL;DR: A novel screening assay is developed that can lead to the identification of compounds that can inhibit EMT initiated by growth factor signaling, and is designed as a high-content screening assay where both cell growth and cell migration can be analyzed simultaneously via time-course imaging in multi-well plates.
Journal ArticleDOI

Metabolism Is Central to Tolerogenic Dendritic Cell Function

Wen Jing Sim, +2 more
- 11 Feb 2016 - 
TL;DR: It is demonstrated that dendritic cell maturation leads to a shift toward a glycolytic metabolic state and preferred use of glucose as a carbon source, which drives differential cellular function and plays a role in pathologies, such as autoimmune disease.