W
Wen-Lin Xu
Researcher at Jiangsu University
Publications - 21
Citations - 439
Wen-Lin Xu is an academic researcher from Jiangsu University. The author has contributed to research in topics: Daunorubicin & MTT assay. The author has an hindex of 11, co-authored 21 publications receiving 418 citations.
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Journal ArticleDOI
Biocompatibility of Fe3O4/DNR magnetic nanoparticles in the treatment of hematologic malignancies
Weiwei Wu,Baoan Chen,Jian Cheng,Jun Wang,Wen-Lin Xu,Li-jie Liu,Guohua Xia,Hu-Lai Wei,Xuemei Wang,Mingming Yang,Liya Yang,Yi Zhang,Chuanlu Xu,Jieyong Li +13 more
TL;DR: Self-assembled Fe3O4-MNPs/DNR appear to be highly biocompatible and safe nanoparticles, and may be suitable for further application in the treatment of hematologic malignancies.
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Combination of tetrandrine as a potential-reversing agent with daunorubicin, etoposide and cytarabine for the treatment of refractory and relapsed acute myelogenous leukemia
TL;DR: TET-DEC was relatively well tolerated in patients with poor risk AML, and had encouraging antileukemic effects, and there was no difference in DNR uptake between responding and non-responding patients.
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Reversal in multidrug resistance by magnetic nanoparticle of Fe3O4 loaded with adriamycin and tetrandrine in K562/A02 leukemic cells.
Baoan Chen,Qian Sun,Xuemei Wang,Feng Gao,Yong-Yuan Dai,Yan Yin,Jia-Hua Ding,Chong Gao,Jian Cheng,Jing-Yuan Li,Xinchen Sun,Ning-Na Chen,Wen-Lin Xu,Hui-Ling Shen,Delong Liu +14 more
TL;DR: It is proposed that Fe3O4-MNPs loaded with ADM and Tet probably have synergetic effect on reversal in multidrug resistance and can enhance the effective accumulation of the drugs in K562/A02.
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Magnetic nanoparticle of Fe3O4 and 5-bromotetrandrin interact synergistically to induce apoptosis by daunorubicin in leukemia cells.
Baoan Chen,Jian Cheng,Ming-fang Shen,Feng Gao,Wen-Lin Xu,Hui-lin Shen,Jia-Hua Ding,Chong Gao,Qian Sun,Xinchen Sun,Hongyan Cheng,Guo-hong Li,Wen-ji Chen,Ning-Na Chen,Li-jie Liu,Xiaomao Li,Xuemei Wang +16 more
TL;DR: In vitro data strongly suggests a potential clinical application of MNP(Fe3O4) and BrTet combination on CML, and confirmed that the distinct synergism effect of that composite on reverse multidrug resistance may owe to the regulation of various proliferative and antiapoptotic gene products.
Journal ArticleDOI
Daunorubicin-loaded magnetic nanoparticles of Fe3O4 overcome multidrug resistance and induce apoptosis of K562-n/VCR cells in vivo
Baoan Chen,Bin-bin Lai,Jian Cheng,Guohua Xia,Feng Gao,Wen-Lin Xu,Jia-Hua Ding,Chong Gao,Xinchen Sun,Cui-Rong Xu,Wen-ji Chen,Ning-Na Chen,Li-jie Liu,Xiaomao Li,Xuemei Wang +14 more
TL;DR: DNR-loaded MNPs-Fe3O4 can overcome MDR in vivo, and the transcriptions and expressions of Bax and caspase-3 in group D were increased significantly when compared with groups A, B, and C.