W
Wen Zhou
Researcher at Guangzhou University of Chinese Medicine
Publications - 3
Citations - 142
Wen Zhou is an academic researcher from Guangzhou University of Chinese Medicine. The author has contributed to research in topics: Virtual screening & Docking (molecular). The author has an hindex of 3, co-authored 3 publications receiving 106 citations.
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Journal ArticleDOI
Identifying novel selective non-nucleoside DNA methyltransferase 1 inhibitors through docking-based virtual screening.
Shijie Chen,Yulan Wang,Wen Zhou,Shanshan Li,Jianlong Peng,Zhe Shi,Junchi Hu,Yu-Chih Liu,Hong Ding,Yijyun Lin,Linjuan Li,Linjuan Li,Sufang Cheng,Jingqiu Liu,Tao Lu,Hualiang Jiang,Hualiang Jiang,Bo Liu,Mingyue Zheng,Cheng Luo +19 more
TL;DR: A novel DNMT1 inhibitor is identified by combining docking-based virtual screening with biochemical analyses and similarity-based analog searching, and compounds DC_501 and DC_517 were found to be more potent than DC_05, which significantly inhibited cancer cell proliferation.
Journal ArticleDOI
Artemisitene activates the Nrf2-dependent antioxidant response and protects against bleomycin-induced lung injury.
Weimin Chen,Shanshan Li,Li Jinwei,Wen Zhou,Shouhai Wu,Shengmei Xu,Ke Cui,Donna D. Zhang,Bo Liu,Bo Liu +9 more
TL;DR: Chen et al. as discussed by the authors identified artemisitene as a novel Nrf2 activator using antioxidant responsive element luciferase assay in MDA-MB-231 cells.
Journal ArticleDOI
Covalent Inhibitors Allosterically Block the Activation of Rho Family Proteins and Suppress Cancer Cell Invasion
Zhongya Sun,Hao Zhang,Yuanyuan Zhang,Liping Liao,Wen Zhou,Fengcai Zhang,Fengcai Zhang,Fulin Lian,Jing Huang,Pan Xu,Rukang Zhang,Wenchao Lu,Mingrui Zhu,Hongru Tao,Feng Yang,Feng Yang,Hong Ding,Shijie Chen,Liyan Yue,Bing Zhou,Naixia Zhang,Minjia Tan,Hualiang Jiang,Kaixian Chen,Kaixian Chen,Bo Liu,C.Q. Liu,Yongjun Dang,Cheng Luo +28 more
TL;DR: A novel allosteric regulatory site within the Rho family is revealed, which can be exploited for anti‐metastasis drug development, and also provides a novel strategy for inhibitor discovery toward “undruggable” protein targets.