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Bing Zhou
Researcher at Chinese Academy of Sciences
Publications - 117
Citations - 3963
Bing Zhou is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Catalysis & Aryl. The author has an hindex of 33, co-authored 113 publications receiving 3240 citations. Previous affiliations of Bing Zhou include University of Michigan.
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Journal ArticleDOI
Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression
Bing Zhou,Jiantao Hu,Fuming Xu,Zhuo Chen,Longchuan Bai,Ester Fernandez-Salas,Mei Lin,Liu Liu,Chao Yie Yang,Yujun Zhao,Donna McEachern,Sally Przybranowski,Bo Wen,Duxin Sun,Shaomeng Wang +14 more
TL;DR: The design, synthesis, and evaluation of a new class of PROTAC BET degraders are presented, and data establish that compound 23 (BETd-260/ZBC260) is a highly potent and efficacious BET degrader.
Journal ArticleDOI
Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor Regression
Chong Qin,Yang Hu,Bing Zhou,Ester Fernandez-Salas,Chao Yie Yang,Liu Liu,Donna McEachern,Sally Przybranowski,Mi Wang,Jeanne A. Stuckey,Jennifer L. Meagher,Longchuan Bai,Zhuo Chen,Mei Lin,Jiuling Yang,Danya N. Ziazadeh,Fuming Xu,Jiantao Hu,Weiguo Xiang,Liyue Huang,Siwei Li,Bo Wen,Duxin Sun,Shaomeng Wang +23 more
TL;DR: A structure-guided design of [1,4]oxazepines as a new class of BET inhibitors is described and the subsequent design, synthesis, and evaluation of proteolysis-targeting chimeric (PROTAC) small-molecule BET degraders are described.
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Rhodium‐Catalyzed Directed Sulfenylation of Arene C ? H Bonds
TL;DR: The rhodium-catalyzed intermolecular direct C-H thiolation of arenes with aryl and alkyl disulfides was developed for the first time and can be selectively achieved, thus providing a straightforward way for selective preparation of ariesnes and dithioethers.
Journal ArticleDOI
Targeted Degradation of BET Proteins in Triple-Negative Breast Cancer
Longchuan Bai,Bing Zhou,Chao Yie Yang,Jiao Ji,Donna McEachern,Sally Przybranowski,Hui Jiang,Jiantao Hu,Fuming Xu,Yujun Zhao,Liu Liu,Ester Fernandez-Salas,Jing Xu,Yali Dou,Bo Wen,Duxin Sun,Jennifer L. Meagher,Jeanne A. Stuckey,Daniel F. Hayes,Shunqiang Li,Matthew J. Ellis,Shaomeng Wang +21 more
TL;DR: The findings show that targeting BET proteins for degradation represents an effective therapeutic strategy for TNBC treatment and a second-generation BET protein degrader, BETd-246, which exhibits superior selectivity, potency, and antitumor activity.
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Rhodium(III)- and iridium(III)-catalyzed C7 alkylation of indolines with diazo compounds.
TL;DR: For the first time, a successful Ir(III)-catalyzed intermolecular insertion of arene C-H bonds into α-diazo compounds is reported.