Wendy L. Inglis

TL;DR: The review indicates that the PPTg is less concerned with the induction of locomotion and more concerned with relating reinforcement with motor output from the dorsal striatum, and forms a 'subsidiary circuit', returning information to striatal circuitry.

TL;DR: The inhibitory influence of the D2 receptor on D1 receptor-stimulated cAMP production was attenuated in ventral striatal slices taken from isolates, suggesting a functional downregulation of D2 receptors.

TL;DR: The present data show that cholinergic neurons in the LDTg, but not the PPTg, regulate the activity of DA-containing neuron in the VTA, which complements previous data showing that cholinesterase inhibitors in the PTTg regulate DA- containing neurons inThe SNc.

TL;DR: By reviewing the literature, the pedunculopontine tegmental nucleus seems to be involved in attentional and possibly also in learning processes, and could be mediated by influencing cortical function via the thalamus, basal forebrain and basal ganglia.

TL;DR: The hypothesis is that the pedunculopontine tegmental nucleus is one critical site through which limbic information concerned with motivation, reinforcement, and the construction of novel associations can gain access to a stream of motor outflow coming from the caudate-putamen and directed toward pontomedullary systems without reference back to the cerebral cortex.