Wenhua Zheng

TL;DR: The current understanding of the NGF signaling in retina and the therapeutic implications in the treatment of glaucoma are discussed.

TL;DR: The potential of three major red wine derived‐polyphenols to protect against toxicity induced by the nitric oxide free radical donors sodium nitroprusside (SNP) and 3‐morpholinosydnonimine (SIN‐1) was examined, suggesting that the neuroprotective abilities of quercetin, resveratrol, and (+)‐catechin result from their antioxidant properties rather than their purported inhibitory effects on intracellular enzymes such as CO

TL;DR: Results indicate that PKC is involved in the neuroprotective action of resveratrol against Aβ‐induced toxicity, with a concentration of 25 μM being maximally effective.

TL;DR: It is likely that aggregated Abeta peptide triggers degeneration of septal neurons, including those expressing the cholinergic phenotype, by phosphorylation of the tau protein activated by mitogen-activated protein kinase and glycogen synthase kinase-3beta, the two kinases known to be involved in the formation of hyperphosphorylated tau in the AD brain.

TL;DR: Therapeutically targeting the FOXO signaling pathway(s) could lead to the discovery of efficacious agents against some cancers, but this requires an enhanced understanding and knowledge of FOXO transcription factors and their regulation and functioning.