scispace - formally typeset
Search or ask a question

Showing papers by "Wilko Wilkening published in 1999"


Proceedings ArticleDOI
17 Oct 1999
TL;DR: Functional images are formed from image sequences by locally analyzing the time-intensity-curves after a bolus injection of contrast agent, and show potential to visualize microcirculation.
Abstract: Contrast agents enable the visualization of bigger blood vessels in the brain, e.g. the circle of Willis, in color- or power mode, which is a challenging task due to the high attenuation of the transtemporal bone window. Moreover, contrast agent specific imaging mode show potential to visualize microcirculation. Such imaging modes, three of which were investigated, mostly exploit non-linear scattering from microbubbles and the destruction of microbubbles by ultrasound. Functional images are formed from image sequences by locally analyzing the time-intensity-curves after a bolus injection of contrast agent.

11 citations


Patent
11 Mar 1999
TL;DR: In this paper, a method of imaging blood with the use of contrast agents is described, where echo signals received in response to each of the imaging pulses are analyzed to determine if the echoes are produced by tissue or by the contrast agent.
Abstract: A method of imaging blood with the use of contrast agents. A sequence or ensemble of imaging pulses is transmitted into a patient. Echo signals received in response to each of the imaging pulses are received and analyzed to determine if the echoes are produced by tissue or by the contrast agent. Echoes produced by the contrast agent are detected by an echo signal that changes in amplitude or a centroid frequency that changes with each imaging pulse. Once the location of the contrast agent has been determined, an image is created whereby the contrast agent is highlighted for view by a physician or sonographer.

4 citations


Journal ArticleDOI
TL;DR: In this article, ausammenfassung Ultraschallkontrastmittel, die ins Blut injiziert werden, stellen meist akustische Streuer in Form of hullenstabilisierten Gasblaschen bereit.
Abstract: Zusammenfassung Ultraschallkontrastmittel, die ins Blut injiziert werden, stellen meist akustische Streuer in Form von hullenstabilisierten Gasblaschen bereit. Die akustischen Eigenschaften dieser Blaschen unterscheiden sich deutlich von denen der im Gewebe vorhandenen Streuer. Im Schallfeld fuhren die Blaschen nichtlineare Schwingungen aus, die von der mechanischen Resonanzfrequenz der Blaschen gepragt sind. Die Beschallung kann eine Anderung der Blaschendurchmesser, eine vollstandige oder teilweise Zerstorung der Hullen sowie eine Spaltung oder Verschmelzung von Blaschen bewirken und damit die akustischen Eigenschaften der Blaschen erheblich verandern. Durch mehrfache Beschallung der Blaschen mit kurzen Pulsen und Auswertung der Echosignalsequenzen lassen sich hochauflosende Bilder berechnen, welche die Verteilung des Kontrastmittels im Gewebe wiedergeben und so die Abbildung kleiner Gefase sowie die Bewertung von Perfusionsverhaltnissen erlauben.