Willi Hunziker

TL;DR: The structural results are evidence that Ser 152 is the nucleophilic residue essential for catalysis, located in the larger N-terminal domain at the C- terminal edge of a doubly wound parallel β-sheet and part of an Asp-His-Ser triad, which is chemically analogous to, but structurally different from, that in the serine proteases.

TL;DR: Immunologic blot and immunoprecipitation analyses indicate that mAbs htr-9 and utr-1 recognize proteins of approximately 55 kDa and 75 kDa, respectively, which provide evidence for the existence of two distinct TNF receptor molecules that contribute to varying extent to the TNF binding by different human cells.

TL;DR: A second class of response elements, composed of directly repeated pairs of motifs (GGTCCA, AGGTCA, or GGGTGA) spaced by three nucleotides, is synergistically activated by RXR and VDR, but only in the presence of both ligands.

TL;DR: The purified recombinant human calretinin from Escherichia coli lysates is purified and a polyclonal antiserum against it is produced and used in the qualitative detection of CR by different methods of immunohistochemistry as well as in the detection ofCR on immunoblots.

TL;DR: In the glomerular layer of the rat olfactory bulb, GABA-LIR, CR-IR and calbindin-IR cells could be considered to be three distinct chemically-defined neuron groups, whereas TH-IR, TRH-Lir and ENK-L IR neurons were regarded as their subpopulations.