William B. Glen

TL;DR: It is demonstrated that binge-like exposure to alcohol during early to middle adolescence results in deficits in PFC-mediated behavioral control in adulthood.

TL;DR: Dual effects of α2‐NA receptor stimulation – membrane hyperpolarization and enhanced temporal integration – together produce an increase in the overall gain of the response of PFC pyramidal neurons to excitatory synaptic input.

TL;DR: Results confirm changes in the PrL and IfL cortex in glutamatergic neurotransmission during extinction learning and demonstrate that manipulation of mGluR5 facilitates extinction of ethanol cues in association with neuronal plasticity.

TL;DR: A tool, “miRmapper”, is described, which identifies the most dominant miRNAs in a miRNA–mRNA network and recognizes similarities between miRNAAs based on commonly regulated mRNAs, and unraveled novel cooperative interactions between mi RNAs from independent families in regulating common target mRN as well as exploiting the Jaccard distance.

TL;DR: Exploration of the “miRNA matrix” regulatory network revealed that miRNAs uniquely expressed in the liver or gut tissue regulated fundamental cellular processes important for both organs, and that commonly expressed mi RNAs in both tissues regulated biological processes that were specific to either the Liver or the gut.