Dongjun Chung

TL;DR: Histone Kbhb represents a new epigenetic regulatory mark that couples metabolism to gene expression, offering a new avenue to study chromatin regulation and diverse functions of β-hydroxybutyrate in the context of important human pathophysiological states, including diabetes, epilepsy, and neoplasia.

TL;DR: A novel statistical approach, GPA (Genetic analysis incorporating Pleiotropy and Annotation), to increase statistical power to identify risk variants through joint analysis of multiple GWAS data sets and annotation information and to jointly analyze five psychiatric disorders with annotation information.

TL;DR: This work develops sparse versions of the recently proposed two PLS-based classification methods using sparse partial least squares (SPLS), and shows that incorporation of SPLS into a generalized linear model (GLM) framework provides higher sensitivity in variable selection for multicategory classification with unbalanced sample sizes between classes.

TL;DR: It is found that FNR occupancy at many target sites is strongly influenced by nucleoid-associated proteins (NAPs) that restrict access to many FNR binding sites, and genome accessibility may also explain the finding that genome-wide F NR occupancy did not correlate with the match to consensus at binding sites.

TL;DR: A background model that accounts for apparent sources of biases such as mappability and GC content is introduced and a flexible mixture model named MOSAiCS for detecting peaks in both one- and two-sample analyses of ChIP-Seq data is developed.