Showing papers by "William Dowhan published in 2004"

TL;DR: The development of strains of microorganisms in which membrane lipid composition can be genetically manipulated in viable cells has provided a set of reagents to probe lipid functions and these mutants have uncovered previously unrecognized roles for lipids and provided in vivo verification for putative functions described in vitro.

TL;DR: The increased passive membrane permeability of the mutant was not abolished, but protein-mediated osmotic stress adaptation to salts and sucrose was recovered and the reduced dependence on Mg2+ and lack of correction by high monovalent salts strongly support the essential nature of the NB properties of MGlcDAG.