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William E. Hoffman
Researcher at University of Illinois at Chicago
Publications - 176
Citations - 5467
William E. Hoffman is an academic researcher from University of Illinois at Chicago. The author has contributed to research in topics: Ischemia & Cerebral blood flow. The author has an hindex of 39, co-authored 176 publications receiving 5297 citations.
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Journal ArticleDOI
Lipid emulsion infusion rescues dogs from bupivacaine-induced cardiac toxicity
TL;DR: It was found that infusing a lipid emulsion during resuscitation from bupivacaine-induced cardiac toxicity substantially improved hemodynamics, pmO2, and pHm and increased survival in dogs.
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Lipid Infusion Accelerates Removal of Bupivacaine and Recovery From Bupivacaine Toxicity in the Isolated Rat Heart
Guy L. Weinberg,Richard Ripper,Patricia Murphy,Lucas Edelman,William E. Hoffman,Gary R. Strichartz,Douglas L. Feinstein +6 more
TL;DR: Findings are consistent with the hypothesis that bupivacaine partitions into the emulsion and supports the concept of a “lipid sink,” and do not exclude other possible mechanisms of action.
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Dexmedetomidine Improves Neurologic Outcome from Incomplete Ischemia in the Rat Reversal by the α2-Adrenergic Antagonist Atipamezole
TL;DR: It is concluded that alpha 2-adrenoreceptor stimulation decreases sympathetic activity and decreases ischemic injury in a model of incomplete cerebral ischemia in rats.
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Fentanyl or dexmedetomidine combined with desflurane for bariatric surgery
TL;DR: Dexmedetomidine, when used to substitute for fentanyl during gastric bypass surgery, attenuates blood pressure and provides postoperative analgesia, which is beneficial for management of bariatric surgery.
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Brain tissue oxygen, carbon dioxide, and pH in neurosurgical patients at risk for ischemia.
TL;DR: It is suggested that brain tissue measures of PO2, PCO2, and pH provide information on the adequacy of cerebral perfusion in neurosurgical patients.