G
Gary R. Strichartz
Researcher at Brigham and Women's Hospital
Publications - 255
Citations - 15333
Gary R. Strichartz is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Sodium channel & Local anesthetic. The author has an hindex of 63, co-authored 254 publications receiving 14571 citations. Previous affiliations of Gary R. Strichartz include Albert Einstein College of Medicine & State University of New York System.
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Journal ArticleDOI
MAP kinase and pain
TL;DR: Central mechanisms of MAPKs, especially ERK, include regulating the activity of glutamate receptors and potassium channels and inducing gene transcription, which contribute to pain sensitization after tissue and nerve injury via distinct molecular and cellular mechanisms.
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Molecular mechanisms of local anesthesia: a review.
TL;DR: In binding to activated and inactivated channels, LAs prevent the conformational changes of activation and antagonize the binding of activator agents that poise channels in activated, open states.
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The inhibition of sodium currents in myelinated nerve by quaternary derivatives of lidocaine
TL;DR: The inhibition of sodium currents by quaternary derivatives of lidocaine was studied in single myelinated nerve fibers and suggests that the drug binds at a site which is about halfway down the electrical gradient from inside to outside of the sodium channel.
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A Peptide c-Jun N-Terminal Kinase (JNK) Inhibitor Blocks Mechanical Allodynia after Spinal Nerve Ligation: Respective Roles of JNK Activation in Primary Sensory Neurons and Spinal Astrocytes for Neuropathic Pain Development and Maintenance
Zhi Ye Zhuang,Yeong-Ray Wen,De Ren Zhang,Tiziana Borsello,Christophe Bonny,Gary R. Strichartz,Isabelle Decosterd,Ru-Rong Ji +7 more
TL;DR: The data suggest that JNK activation in the DRG and spinal cord play distinct roles in regulating the development and maintenance of neuropathic pain, respectively, and that spinal astrocytes contribute importantly to the persistence of mechanical allodynia.
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Purification and characterization of chlorotoxin, a chloride channel ligand from the venom of the scorpion
TL;DR: It is demonstrated that the venom of the scorpion Leiurus quinquestriatus blocks small-conductance Cl- channels, derived from epithelial cells, when applied to the cytoplasmic surface, using a small basic peptide of 4,070 Da.