W
William Fletcher
Researcher at University College London
Publications - 3
Citations - 689
William Fletcher is an academic researcher from University College London. The author has contributed to research in topics: Multiple sequence alignment & Divergence (statistics). The author has an hindex of 3, co-authored 3 publications receiving 627 citations.
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Journal ArticleDOI
INDELible: a flexible simulator of biological sequence evolution.
William Fletcher,Ziheng Yang +1 more
TL;DR: A portable and flexible application for generating nucleotide, amino acid and codon sequence data by simulating insertions and deletions (indels) as well as substitutions, which should be useful for evaluating the performance of many inference methods, including those for multiple sequence alignment, phylogenetic tree inference, and ancestral sequence, or genome reconstruction.
Journal ArticleDOI
The Effect of Insertions, Deletions and Alignment Errors on the Branch-Site Test of Positive Selection
William Fletcher,Ziheng Yang +1 more
TL;DR: It is found that insertions and deletions do not cause excessive false positives if the alignment is correct, but alignment errors can lead to unacceptably high false positives, and it is important to use reliable alignment methods.
Journal ArticleDOI
Evolutionary distances in the twilight zone--a rational kernel approach.
Roland F. Schwarz,William Fletcher,Frank Förster,Benjamin Merget,Matthias Wolf,Jörg Schultz,Florian Markowetz +6 more
TL;DR: A new evolutionary distance metric is proposed that uses finite-state transducers to create a biologically motivated similarity score which models substitutions and indels, and does not depend on a multiple sequence alignment.