Showing papers by "William G. Austen published in 1968"

Surgical Treatment of Papillary-Muscle Rupture Complicating Myocardial Infarction

Abstract: Mitral-valve replacement was performed in five patients with ruptured papillary muscle secondary to myocardial infarction. In each case severe mitral regurgitation was suggested by the sudden appearance of a systolic murmur followed by progressive congestive heart failure. The diagnosis was confirmed by the presence of giant systolic waves in the pulmonary wedge tracing in four and of severe mitral regurgitation by left ventricular angiography in one. Open-heart surgery was performed at intervals of 14 days to 14 months after the acute infarct; four of the patients survive and are now doing well.

Gastrointestinal Bleeding Occurring in Patients With Acquired Valvular Heart Disease

Abstract: OCCULT gastrointestinal bleeding has been previously reported to be a common complication in patients with the clinical diagnosis of aortic stenosis. 1-3 To further define this possible relationship, a group of patients in which the diagnosis of aortic valve disease had been proven surgically was reviewed. Patients The group of patients consists of 211 with aortic valve replacements for aortic stenosis or regurgitation or both and 110 with mitral valve replacements for mitral stenosis or regurgitation or both who were operated on from July 1963 to December 1966 at the Massachusetts General Hospital. The cases of mitral replacements were reviewed to provide a similarly ill group of patients as a reasonably comparable control group for those with aortic stenosis. The gastrointestinal bleeding was considered significant if four consecutive guaiac stool examinations were positive with or without hematemesis, drop in the hematocrit reading, or necessity for transfusion. Only those patients

Antithrombogenic cellulose film

Abstract: A careful solvent-exchange procedure followed by liquid-phase reaction of ethyleneimine with cellulose film in a nonpolar solvent provides an effective method of uniformly aminoethylating cellulose The protonated aminoethyl groups on the cellulose can then ionically bind heparin, a blood anticoagulant Heparinized aminoethylated cellulose tubing at low levels of aminoethylation (ca 02–03% nitrogen) exhibited excellent antithrombogenic properties as well as excellent mechanical strength properties The in vitro tests demonstrated indefinitely long whole-blood clotting times with normal thrombin times In the in vivo experiments, the heparinized aminoethylated cellulose tubing provided extended patency when implanted intravascularly in the regions of low blood flow rate (infra renal inferior vena cava of dogs) A principal use of this film is in the artificial kidney