An essential textbook for any student or researcher in biology needing to design experiments, sample programs or analyse the resulting data The text begins with a revision of estimation and hypothesis testing methods, covering both classical and Bayesian philosophies, before advancing to the analysis of linear and generalized linear models Topics covered include linear and logistic regression, simple and complex ANOVA models (for factorial, nested, block, split-plot and repeated measures and covariance designs), and log-linear models Multivariate techniques, including classification and ordination, are then introduced Special emphasis is placed on checking assumptions, exploratory data analysis and presentation of results The main analyses are illustrated with many examples from published papers and there is an extensive reference list to both the statistical and biological literature The book is supported by a website that provides all data sets, questions for each chapter and links to software

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Experimental Design and Data Analysis for Biologists

From the Publisher:
Phadke was trained in robust design techniques by Genichi Taguchi, the mastermind behind Japanese quality manufacturing technologies and the father of Japanese quality control. Taguchi's approach is currently under consideration to be adopted as a student protocol with the US govrnment. The foreword is written by Taguchi. This book offers a complete blueprint for structuring projects to achieve rapid completion with high engineering productivity during the research and development phase to ensure that high quality products can be made quickly and at the lowest possible cost. Some topics covered are: orthogonol arrays, how to construct orthogonal arrays, computer-aided robutst design techniques, dynamic systems design methods, and more.

Quality Engineering Using Robust Design

Fenton chemistry encompasses reactions of hydrogen peroxide in the presence of iron to generate highly reactive species such as the hydroxyl radical and possibly others. In this review, the complex mechanisms of Fenton and Fenton-like reactions and the important factors influencing these reactions, from both a fundamental and practical perspective, in applications to water and soil treatment, are discussed. The review covers modified versions including the photoassisted Fenton reaction, use of chelated iron, electro-Fenton reactions, and Fenton reactions using heterogeneous catalysts. Sections are devoted to nonclassical pathways, by-products, kinetics and process modeling, experimental design methodology, soil and aquifer treatment, use of Fenton in combination with other advanced oxidation processes or biodegradation, economic comparison with other advanced oxidation processes, and case studies.

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Advanced Oxidation Processes for Organic Contaminant Destruction Based on the Fenton Reaction and Related Chemistry

Alternative formulations of Levene's test statistic for equality of variances are found to be robust under nonnormality. These statistics use more robust estimators of central location in place of the mean. They are compared with the unmodified Levene's statistic, a jackknife procedure, and a χ2 test suggested by Layard which are all found to be less robust under nonnormality.

Robust Tests for the Equality of Variances

PREFACE. 1. A WORKED EXAMPLE. 1.1 A simple model. 1.2 Modulus version of the simple model. 1.3 Six--factor version of the simple model. 1.4 The simple model 'by groups'. 1.5 The (less) simple correlated--input model. 1.6 Conclusions. 2. GLOBAL SENSITIVITY ANALYSIS FOR IMPORTANCE ASSESSMENT. 2.1 Examples at a glance. 2.2 What is sensitivity analysis? 2.3 Properties of an ideal sensitivity analysis method. 2.4 Defensible settings for sensitivity analysis. 2.5 Caveats. 3. TEST CASES. 3.1 The jumping man. Applying variance--based methods. 3.2 Handling the risk of a financial portfolio: the problem of hedging. Applying Monte Carlo filtering and variance--based methods. 3.3 A model of fish population dynamics. Applying the method of Morris. 3.4 The Level E model. Radionuclide migration in the geosphere. Applying variance--based methods and Monte Carlo filtering. 3.5 Two spheres. Applying variance based methods in estimation/calibration problems. 3.6 A chemical experiment. Applying variance based methods in estimation/calibration problems. 3.7 An analytical example. Applying the method of Morris. 4. THE SCREENING EXERCISE. 4.1 Introduction. 4.2 The method of Morris. 4.3 Implementing the method. 4.4 Putting the method to work: an analytical example. 4.5 Putting the method to work: sensitivity analysis of a fish population model. 4.6 Conclusions. 5. METHODS BASED ON DECOMPOSING THE VARIANCE OF THE OUTPUT. 5.1 The settings. 5.2 Factors Prioritisation Setting. 5.3 First--order effects and interactions. 5.4 Application of Si to Setting 'Factors Prioritisation'. 5.5 More on variance decompositions. 5.6 Factors Fixing (FF) Setting. 5.7 Variance Cutting (VC) Setting. 5.8 Properties of the variance based methods. 5.9 How to compute the sensitivity indices: the case of orthogonal input. 5.9.1 A digression on the Fourier Amplitude Sensitivity Test (FAST). 5.10 How to compute the sensitivity indices: the case of non--orthogonal input. 5.11 Putting the method to work: the Level E model. 5.11.1 Case of orthogonal input factors. 5.11.2 Case of correlated input factors. 5.12 Putting the method to work: the bungee jumping model. 5.13 Caveats. 6. SENSITIVITY ANALYSIS IN DIAGNOSTIC MODELLING: MONTE CARLO FILTERING AND REGIONALISED SENSITIVITY ANALYSIS, BAYESIAN UNCERTAINTY ESTIMATION AND GLOBAL SENSITIVITY ANALYSIS. 6.1 Model calibration and Factors Mapping Setting. 6.2 Monte Carlo filtering and regionalised sensitivity analysis. 6.2.1 Caveats. 6.3 Putting MC filtering and RSA to work: the problem of hedging a financial portfolio. 6.4 Putting MC filtering and RSA to work: the Level E test case. 6.5 Bayesian uncertainty estimation and global sensitivity analysis. 6.5.1 Bayesian uncertainty estimation. 6.5.2 The GLUE case. 6.5.3 Using global sensitivity analysis in the Bayesian uncertainty estimation. 6.5.4 Implementation of the method. 6.6 Putting Bayesian analysis and global SA to work: two spheres. 6.7 Putting Bayesian analysis and global SA to work: a chemical experiment. 6.7.1 Bayesian uncertainty analysis (GLUE case). 6.7.2 Global sensitivity analysis. 6.7.3 Correlation analysis. 6.7.4 Further analysis by varying temperature in the data set: fewer interactions in the model. 6.8 Caveats. 7. HOW TO USE SIMLAB. 7.1 Introduction. 7.2 How to obtain and install SIMLAB. 7.3 SIMLAB main panel. 7.4 Sample generation. 7.4.1 FAST. 7.4.2 Fixed sampling. 7.4.3 Latin hypercube sampling (LHS). 7.4.4 The method of Morris. 7.4.5 Quasi--Random LpTau. 7.4.6 Random. 7.4.7 Replicated Latin Hypercube (r--LHS). 7.4.8 The method of Sobol'. 7.4.9 How to induce dependencies in the input factors. 7.5 How to execute models. 7.6 Sensitivity analysis. 8. FAMOUS QUOTES: SENSITIVITY ANALYSIS IN THE SCIENTIFIC DISCOURSE. REFERENCES. INDEX.

Sensitivity Analysis in Practice: A Guide to Assessing Scientific Models

Response surface methodology, an experimental strategy initially developed and described by Box and Wilson, has been employed with considerable success in a wide variety of situations, especially in the fields of chemistry and chemical engineering. It is the purpose of this paper to review the literature of response surface methodology, emphasizing especially the practical applications of the method. A comprehensive bibliography is included.

A Review of Response Surface Methodology: A Literature Survey*

Fractional factorial designs-especially the twolevel designs-are useful in a variety of experimental situations, for example, (i) screening studies in which only a subset of the variables is expected to be important, (ii) research investigations in which certain interactions are expected to be negligible and (iii) experimental programs in which groups of runs are to be performed sequentially, ambiguities being resolved as the investigation evolves (see Box, Hunter and Hunter, 1978). The literature on fractional factorial designs is extensive. For references before 1969, see the comprehensive bibliography of Herzberg and Cox (1969). For more recent references, see Daniel (1976) and Joiner (1975-79). A useful concept associated with 2k-P fractional factorial designs is that of resolution (Box and Hunter, 1961). A design is of resolution R if no cfactor effect is confounded with any other effect containing less than R c factors. For example, a design of resolution III does not confound main effects with one another but does confound main effects with two-factor interactions, and a design of resolution IV does not confound main effects with two-factor interactions but does confound two-factor interactions with one another. The resolution of a two-level fractional factorial design is the length of the shortest word in the defining relation. Usually an experimenter will prefer to use a design which has the highest

Minimum Aberration 2k-p Designs

We review major developments in the design of experiments, offer our thoughts on important directions for the future, and make specific recommendations for experimenters and statisticians who are students and teachers of experimental design, practitioners of experimental design, and researchers jointly exploring new frontiers. Specific topics covered are optimal design, computer-aided design, robust design, response surface design, mixture design, factorial design, block design, and designs for nonlinear models.

Experimental Design: Review and Comment

In most statistical literature on the design of experiments it is assumed that the correct form of the mathematical model is known and the problem is to select the experimental conditions so that some criterion is satisfied, for example, the parameters are estimated with maximum precision. Such an approach, however, ignores one important question that often confronts experimenters who, instead of having only one model known to be correct, have a number of rival candidate models to consider. Such situations can arise, for example, at the outset of investigations on the kinetics of solid-catalyzed gas reactions in chemical engineering. Often the immediate question in these circumstances is: how should experiments be planned so that the inadequate models can be detected and hence eliminated most eliiciently? In this paper a sequential design procedure is proposed for discriminating between two rival models. The basic idea is to select for the next experimental point that at which the models differ the most. ...

https://www.jstor.org/stable/info/1266591

Designs for Discriminating Between Two Rival Models

In this paper the question of what is the best setting for the target value of an industrial process is explored. A simple graphical procedure is described which takes into account the regular and reduced selling prices, the give-away cost, and the proc..

William G. Hunter

Papers

A Review of Response Surface Methodology: A Literature Survey*

Minimum Aberration 2k-p Designs

Experimental Design: Review and Comment

Designs for Discriminating Between Two Rival Models

Determining the Most Profitable Target Value for a Production Process